Navigating the gut-bone axis: The pivotal role of Coprococcus3 in osteoporosis prevention through Mendelian randomization.

Osteoporosis (OP) constitutes a notable public health concern that significantly impacts the skeletal health of the global aging population. Its prevalence is steadily escalating, yet the intricacies of its diagnosis and treatment remain challenging. Recent investigations have illuminated a profound interlink between gut microbiota (GM) and bone metabolism, thereby opening new avenues for probing the causal relationship between GM and OP.

[Surgical treatment of dumbbell tumor complicating with vertebral destruction in cervical spine].

Objective: To explore the feasibility and efficacy of operating through an anterior approach in the treatment of dumbbell tumor complicating with vertebral destruction in cervical spine.

Methods: Surgical procedures were performed through an anterior approach in 7 cases of dumbbell tumor complicating with vertebral and transverse process destruction during the period of May 2004 to February 2009. Bone graft and internal fixation were implemented after tumor removal.

BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and risk of fracture in Caucasians: a meta-analysis.

Context: Vitamin D receptor (VDR) gene polymorphisms have been strongly associated with bone mineral density in some studies. However, in a recent meta-analysis, no relationship of the VDR BsmI or TaqI polymorphism and fracture risk was found in the meta-analysis of published data.

Objective And Design: Our meta-analysis studied whether a relationship exists between BsmI, TaqI, ApaI and FokI polymorphisms in the VDR gene and risk of fracture.