Nobiletin inhibits cell growth through restraining aerobic glycolysis via PKA-CREB pathway in oral squamous cell carcinoma.

Background/aim: Nobiletin is a polymethoxylated flavone enriched in Citrus and is used as an important drug in traditional Chinese medicine for various kinds of diseases. Among its multiple functions, it has shown that nobiletin inhibits proliferation of various cancer cells. However, it is unclear whether nobiletin inhibits the growth of oral squamous cell carcinoma (OSCC) cells.

Isolated Influences of Surgery Repair on Maxillofacial Growth in Complete Unilateral Cleft Lip and Palate.

Purpose: The purpose of this study was to investigate the maxillofacial morphologic characteristics of children with complete unilateral cleft lip and palate (UCLP) with and without surgical correction and better understand the relation between surgery and inhibition of maxillary growth.

Material And Methods: Lateral cephalometric radiography was performed in 3 groups of 9-year-old children: 1) 20 whose UCLP was repaired in infancy; 2) 20 who had no surgical repair or any relevant treatments; and 3) 20 without UCLP who served as controls.

Results: Marked morphologic deviations of patients in groups 1 and 2 compared with the control group were observed in the cranial base angle, maxillary heights, length and shape of the mandible, and anteroposterior jaw relation.

[Infections of the head and neck leading to descending necrotizing mediastinitis: management of 9 cases].

Objective: To report nine cases of descending necrotizing mediastinitis (DNM) and to summarize the management experience.

Methods: Between December 2005 and December 2008, nine patients (mean age, 55.7 years; age range, 38 to 78 years) with DNM were treated.

[Application of parasymphyseal mandible osteotomy combined with set-back tongue flap in treatment of tongue base carcinoma].

Objective: To evaluate the efficacy of the approach of parasymphyseal mandible osteotomy combined with set-back tongue flap in treatment of tongue base carcinoma.

Methods: In total 18 patients with cancer of tongue base, 13 were males and 5 females aged of 30 to 65 y (average 52.9 y).