Identification of a novel frameshift mutation in PITX2 gene in a Chinese family with Axenfeld-Rieger syndrome.

Objective: Axenfeld-Rieger syndrome (ARS) is phenotypically and genetically heterogeneous. In this study, we identified the underlying genetic defect in a Chinese family with ARS.

Methods: A detailed family history and clinical data were recorded.

Bromfenac sodium 0.1%, fluorometholone 0.1% and dexamethasone 0.1% for control of ocular inflammation and prevention of cystoid macular edema after phacoemulsification.

Purpose: To compare bromfenac sodium 0.1%, fluorometholone 0.1% and dexamethasone 0.

[Clinical evaluation on the coaxial 1.8 mm microincision cataract surgery].

Objective: To study and compare the outcomes of coaxial 1.8 mm microincision phacoemulsification with conventional coaxial 3 mm small-incision cataract surgery.

Methods: A randomized prospective study was conducted on 89 patients with age-related cataract: coaxial 1.

[Computer construction and analysis of protein models of mutant fibrillin-1 gene in Marfan's syndrome].

Objective: Fibrillin-1, the major constituent of extracellular microfibrils, plays an important role in the molecular pathogenesis of Marfan syndrome (MFS, #54700). The aim of this study was to analyze protein models of the mutation of the fibrillin-1 (FBN1) gene on Arg545Cys and Arg1530Cys which have been reported to cause predominant ectopia lentis in Chinese patients.

Methods: We constructed and analyzed the protein models of the mutant FBN1 gene on Arg545Cys and Arg1530Cys.