Copper(I)-Catalyzed Dearomatization of Benzofurans with 2-(Chloromethyl)anilines through Radical Addition and Cyclization Cascade.

Herein, we described a copper(I)-catalyzed dearomatization of benzofurans with 2-(chloromethyl)anilines to prepare various tetrahydrobenzofuro[3,2-]quinolines and 2-(quinolin-2-yl)phenols in good to excellent yields through radical addition and an intramolecular cyclization process. Mechanistic studies revealed that 2-(chloromethyl)anilines served as radical precursors. The present method features broad substrate scope, good functional group tolerance, quinoline scaffold diversity, and radical addition dearomatization of benzofurans.

[Design and development of quality traceability system for circulation of Chinese herbal medicine based on blockchain and NB-IOT].

The safety of traditional Chinese medicine is an important issue of people's livelihood in China. The traceability process on the quality of traditional Chinese medicine is characterized by long duration, many links, and complex circulation process of traditional Chinese medicine, so the establishment and improvement of traceability system is key to the modernized development of traditional Chinese medicine. The circulation traceability system of Chinese medicinal materials, as an important part of traceability system for Chinese traditional medicine, is built according to the GSP standard by using the block chain technology to ensure the security of information circulation and the low energy consumption of NB-IOT technology, build a safe and reliable system with wide coverage and low cost technology, and provide safe and reliable technical support for the data collection and transmission.