Publications by authors named "Chong-Yao Li"
Intracellular Ca dysregulation is a key marker in septic cardiac dysfunction; however, regulation of the classic Ca regulatory modules cannot successfully abolish this symptom. Here we show that the knockout of transient receptor potential canonical (TRPC) channel isoforms TRPC1 and TRPC6 can ameliorate LPS-challenged heart failure and prolong survival in mice. The LPS-triggered Ca release from the endoplasmic reticulum both in cardiomyocytes and macrophages is significantly inhibited by Trpc1 or Trpc6 knockout.
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- Cardiac dysfunction, which is a problem with how the heart works, can happen during a condition called endotoxemia, and a specific enzyme called PFKFB3 seems to be involved in this issue.
- Researchers did experiments on mice to see how PFKFB3 affects heart damage caused by an injection of a substance called LPS, and they found that blocking PFKFB3 helped protect the heart.
- The study shows that by stopping PFKFB3, not only did the heart function improve, but it also reduced harmful inflammation and cell death in the heart cells during this sickness.