[F-FDG PET/CT Metabolic Parameters and Circulating Tumour DNA Mutation Abundance in Diffuse Large B-Cell Lymphoma: Correlation and Survival Analysis].

Objective: To investigate the correlation between Fluoro-deoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) metabolic parameters and peripheral blood circulating tumour DNA (ctDNA) in patients with diffuse large B-cell lymphoma (DLBCL), and the prognostic value of these two types of parameters in predicting progression-free survival (PFS).

Methods: Clinical, PET/CT and ctDNA data of DLBCL patients who underwent peripheral blood ctDNA testing and corresponding PET/CT scans during the same period were retrospectively analyzed. At the time of ctDNA sampling and PET scan, patients were divided into baseline and relapsed/refractory (R/R) groups according to different disease conditions.

[Roles of PET/CT in Predicting the Prognosis of Diffuse Large B Cell Lymphoma Patients Treated with Chimeric Antigen Receptor T Cell Therapy].

Objective: To investigate the prognosis prediction value of PET/CT in DLBCL patients treated with CAR-T therapy.

Methods: The effects of PET/CT were retrospectively explored on 13 R/R DLBCL patients who were treated with CAR-T therapy. Parameters reflecting tumor metabolic burden, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were measured before and after CAR-T treatment.

Interim response in diffuse large B cell lymphoma on CT: what is the optimal size reduction (ΔSPD) for predicting outcome?

Objectives: To investigate whether there was an optimal interim size reduction (iΔSPD) cutoff value that could discriminate diffuse large B cell lymphoma (DLBCL) patients with poor prognosis.

Methods: This retrospective study enrolled 265 newly diagnosed DLBCL patients with baseline and interim (after 3 cycles) contrast-enhanced computed tomographic scan (CECT) available. Two radiologists evaluated CECT images and selected target lesions according to the Lugano Response Criteria.

The prognostic role of 18F-FDG PET/CT baseline quantitative metabolic parameters in peripheral T-cell lymphoma.

The aim of this study is to investigate the prognostic significance of baseline maximum standard uptake value (SUVmax), whole body SUVmax (WBSUVmax), whole body metabolic tumor volume (WBMTV) and whole body total lesion glycolysis (WBTLG) in patients with peripheral T-cell lymphoma (PTCL). Eighty patients with PTCL who underwent pretreatment F-PET/CT were enrolled in this study. WBMTV and WBTLG were computed by using the margin threshold of SUV>3.

Prognostic Value of Baseline and Interim Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on 18F-FDG PET-CT in Patients with Follicular Lymphoma.

Purpose: The purpose of this study was to investigate the prognostic significance of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) in patients with follicular lymphoma (FL) at baseline and mid-treatment with 18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scans.

Methods: The study analyzed data from 48 patients with FL who were treated in Jiangsu Province Hospital and reviewed their baseline PET-CT scans. TMTV and TLG were computed by using the absolute value of 2.

[F-FDG PET/CT Manifestation and Clinical Analysis of Primary Hepatic Lymphoma].

Objective: To explore the imaging characteristics of F-FDG PET-CT and clinical presentation of patients with primary hepatic lymphoma (PHL).

Methods: The F-FDG PET-CT image data of 6 patients with pathologically diagnosed PHL, were retrospectively analyzed.

Results: The six patients included 4 male cases and 2 female cases, with median age of 65 years old , and all the cases were diagnosed as diffuse large B-cell lymphoma.

[F-FDG PET/CT Manifestation and Clinical Analysis of Subcutaneous Panniculitis-Like T-Cell Lymphoma].

Objective: To explore the clinical presentation, imaging characteristics of F-FDG PET/CT and prognosis of patients with subcutaneous panniculitis-like T-cell lymphoma (SPTCL).

Methods: The images and clinical data of 7 patients with pathologically confirmed SPTCL who underwent F-FDG PET/CT were retrospectively analyzed.

Results: Six patients displayed multiple subcutaneous nodules or deeply seated plaques, most commonly on the extremities and trunk, and one patient showed a single lesion on his face.

[Value of Pretherapeutic F-FDG PET/CT in the Diagnosis, Staging and Prognosis Evaluation of Adult Burkitt's Lymphoma].

Objective: To investigate the value of pretherapeutic F-FDG PET/CT in the focus detection, staging and prognosis evaluation of adult Burkitt's lymphoma(BL).

Methods: The clinical data and detection results of F-FDG PET/CT scan of 18 patients with BL before the treatment from December 2008 to February 2015 were analyzed retrospectively. The lesions distribution were observed, the maximal standard uptake value(SUV) of F-FDG by lesions and the maximal diameter of lymph nodes were measured.

[Clinical Value of F-FDG PET/CT for Patients with B Cell Lymphoma-Associated Hemophagocytic Syndrome].

Objective: To investigate the clinical value of F-FDG PET/CT for patients with B cell lymphoma-associated hemophagocytic syndrome.

Methods: The clinical characteristics, laboratory parameters and F-FDG PET/CT data of 23 newly diagnosed patients sufferred from B cell lymphoma-associated hemophagocytic syndrome were retrospectively analyzed. The correlation between PET and laboratory parameters were determined using Spearman correlation test.

Investigating Factors Associated with Thymic Regeneration after Chemotherapy in Patients with Lymphoma.

The factors involved in thymus regeneration after chemotherapy has not been sufficiently explored. This study was aimed to identify the clinical characteristics and single-nucleotide polymorphisms in the gene () encoding IL-7Rα associated with thymus renewal after chemotherapy in Chinese Han individuals with lymphoma. The dynamics of thymic activity in 134 adults with Hodgkin lymphoma (HL) and B cell lymphoma from baseline to 12 months post-chemotherapy were analyzed by assessing thymic structural changes using serial computed tomography scans and correlating these with measurements of thymic output by concurrent analysis of single-joint T-cell receptor excision circles (sjTREC) and CD31 recent thymic emigrants (RTE) in peripheral blood.

[PET-CT Manifestation and Clinical Analysis of Waldenstrom Macroglobulinemia].

Objective: To investigate the PET-CT manifestation and clinical features of patients with Waldenstrom macroglobulinemia(WM) .

Methods: The clinical features, laboratorial examination results and PET-CT manifestation of 12 patients with WM were analyzed retrospectively.

Results: The average age of 12 patients with WM was 63.

Prognostic value of whole-body SUVmax of nodal and extra-nodal lesions detected by 18F-FDG PET/CT in extra-nodal NK/T-cell lymphoma.

We analyzed data from 54 newly-diagnosed persons with extra-nodal natural killer/T-cell (NK/T) lymphoma, who had a pretreatment 18F-FDG PET/CT study, to determine whether the sum of SUVmax of all the nodal and extra-nodal lesions predicted progression-free survival (PFS) and/or overall survival (OS). Three models (WB1SUVmax, WB2SUVmax, WB3SUVmax) based on the basis of the sum of SUVmax of the whole-body SUVmax of 11 nodal and 10 extra-nodal lesions were tested. The discrimination value of these models was evaluated using time-dependent receiver-operator characteristic (ROC) curves and corresponding areas under the curve (AUC) in training and validation cohorts.

Thymic hyperplasia after chemotherapy in adults with mature B cell lymphoma and its influence on thymic output and CD4(+) T cells repopulation.

To investigate the thymic regenerative potential in adults accepting chemotherapy for lymphoma. The dynamics of thymic activity in 54 adults from baseline to 12 mo post-chemotherapy was analyzed by assessing thymic structural changes with serial computed tomography (CT) scans, and correlating these with measurements of thymic output by concurrent analysis of single-joint (sj) T-cell receptor excision circles (sjTREC) and CD31(+) recent thymic emigrants (RTE) in peripheral blood. Furthermore, the consequence of thymic renewal on peripheral CD4(+) T cell recovery after chemotherapy was evaluated.

[Prognostic Value of Maximum Standard Uptake on Pretreatment ¹⁸F-FDG PET/CT Scan in Newly Diagnosed Follicular Lymphoma].

Objective: To determine the prognostic value of maximum standard uptake (SUV(max)) of pretreatment ¹⁸F-FDG PET/CT scan in newly diagnosed follicular lymphoma (FL).

Methods: The clinical data and detection results of ¹⁸F-FDG PET/CT scan of 30 patients with FL before treatment from November 2005 to October 2013 were analyzed retrospectively. The relation of SUV(max) with prognostic factors, therapeutic efficacy and survival time was evaluated in term of pathologic grade, FLIPI2 absence and presence of bulky disease and bone marrow involvement, clinical indicators and outcome of treatment.

[Value of PET/CT after Chemotherapy for Evaluating Therapentic Efficacy of Patients with Diffuse Large B-cell Lymphoma].

Objective: To investigate the value of PET/CT after chemotherapy for evaluating therapeutic efficacy of patients with diffuse large B-cell lymphoma (DLBCL).

Methods: (18)F-FDG PET/CT was performed before and after 6-8 cycles of chemotherapy in 73 newly diagnosed patients with DLBCL from September 2005 to January 2012. The results of pre-treatment PET/CT was compared with results of post-treatment PET/CT.

Exploring the role of bone marrow increased FDG uptake on PET/CT in patients with lymphoma-associated hemophagocytic lymphohistiocytosis: a reflection of bone marrow involvement or cytokine storm?

The role of 18F-2-fluoro-2-deoxy-D-glucose (FDG) uptake of bone marrow (BM) on positron emission tomography/computed tomography (PET/CT) in patients with lymphoma-associated hemophagocytic lymphohistiocytosis (LA-HLH) remains uncertain. This retrospective study included 34 LA-HLH patients who underwent both PET/CT and comprehensive BM examinations prior to treatment. Comparison between PET/CT and BM examinations for the assessment of bone marrow involvement (BMI) indicated statistical difference (p = 0.

[Application of 18F-FDG PET/CT images in the newly diagnosed extranodal NK/T cell lymphoma].

Objective: This study was to explore the use value of (18)F-FDG PET/CT in patients with extranodal NK/T cell lymphoma (ENKTL).

Methods: Both PET/CT and CT images were retrospectively analyzed in 43 newly diagnosed patients with ENKTL, and the anatomical position, extent of foci, subtypes, staging and therapeutic regimen determined by both these 2 imaging methods were compared, and relationship between the maximum standard uptake value (SUV(max)) and subtypes, different staging and constitutional symptoms were evaluated.

Results: The top four anatomical positions involved were nose (76.

Thymic hyperplasia following chemotherapy in adults with lymphoma: (18)F-fluorodeoxyglucose positron emission tomography/computed tomography findings and correlation with T cell repopulation.

Thymic hyperplasia (TH) after chemotherapy is an infrequent phenomenon in adults. This study analyzed the incidence and metabolic activity of TH on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in this population. By reviewing 471 PET/CT recordings of 211 adults with lymphoma, increased FDG uptake within an enlarged thymus regarded as TH was observed in 27 patients aged 18-53 years.

The significance of 18F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis.

This study was aimed to investigate the significance of 18F-FDG PET/CT in secondary hemophagocytic lymphohistiocytosis (sHLH) patients. A total of 18 patients received 18F-FDG PET/CT scan at initial diagnosis. All patients (18/18) had at least 3 organs involved, with increased FDG metabolism in different degrees.