Publications by authors named "Chong-Tao Xu"
Condylar-base-associated multiple mandibular fractures are more prevalent than single ones. Direct trauma to mandibular symphysis, body or angle are prone to induce indirect condylar fracture. However, little is known about the effects of various rigid internal fixation modalities in condylar base for relevant multiple mandibular fractures, especially when we are confused in the selection of operative approach.
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- Previous studies indicated that patients with bipolar depressive disorder (BDd) or unipolar depressive disorder (UDd) exhibit abnormalities in cerebral metabolites due to issues in specific brain regions.
- A study involving 13 BDd patients, 20 UDd patients, and 20 healthy controls analyzed the concentrations of 5 cerebral metabolites across different subregions of gray matter, including key areas like the medial frontal cortex and anterior cingulate cortex.
- Results showed significant differences in metabolite levels (like higher glutamate-glutamine in BDd compared to UDd) and highlighted various interactions, suggesting that cerebral metabolite concentrations relate to the severity of the conditions in different brain regions.
The dental pulp contains a relatively low number of stem cells; however, it is considered to be a promising source of stem cells for use in regenerative therapy. To date, it has remained elusive whether there are certain differences in the dental pulp stem cells (DPSCs) from donors of different ages. In the present study, DPSC lines were derived using teeth from children, adolescents, adults and aged donors.
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- This study evaluated the effectiveness of bioabsorbable internal fixation devices on maxillary Lefort I fractures using biomechanical analysis and 3D modeling.
- It revealed that the fixation with two bioabsorbable plates was unstable, while zygomaticomaxillary pillar fixation proved to be more stable.
- The findings suggest that the stability of fracture fixation is affected by molar occlusion, enhancing the understanding of bioabsorbable materials in dental applications.
Aim: We utilized single-voxel 1H magnetic resonance spectroscopy to determine biochemical abnormalities related to major depressive disorder (MDD) in the bilateral dorsolateral prefrontal cortex, anterior cingulate cortex (ACC), and cerebellar hemisphere before and after antidepressant treatment.
Methods: Fifteen adult MDD patients and 15 age- and sex-matched healthy controls were involved. Magnetic resonance spectroscopy of the brain was conducted in all subjects at the beginning of the study and the depressed subjects were reassessed after 8 weeks of antidepressant treatment.
[Finite element study of maxillary Le Fort-I osteotomy with rigid internal fixation].
Zhonghua Zheng Xing Wai Ke Za Zhi
May 2010
Objective: To study the biomechanical characteristic of maxillary Le fort- I osteotomy with rigid internal fixation (RIF) , so as to choose best fixation method.
Methods: The 3-dimensional finite element models of maxillary Le Fort-I osteotomy with 9 kinds of RIF methods were established. Then the models were divided into three groups to calculate the stress distribution of the maxilla and the displacement of bone segment under 3 kinds of occlusion condition.
Objective: Establish the three-dimensional finite element models of mandibular bilateral sagittal split ramus osteotomy (BSSRO) with rigid internal fixation (RIF), for further study of BSSRO.
Methods: CT scanned technology and the finite element software (ANSYS) were used to establish the original three-dimensional model of mandible, modify the model to animate the BSSRO, then establish the model of RIF, last mesh the model to establish the finite element model of BSSRO with RIF. Apply 100 N occlusion force at the central incisor; calculate the stress distribution of the mandible and the RIF.
Article Synopsis
- Previous research indicated that phenytoin might protect the hippocampus from chronic stress damage, but its ability to reverse stress-related issues was unclear.
- The study found that while chronic stress increased motor activity in rats, phenytoin did not change this; however, it successfully reversed long-term memory deficits related to stress as observed through water maze tests.
- Electrophysiological measurements showed that phenytoin helped maintain long-term potentiation (LTP) in the hippocampal CA1 region, suggesting it might be beneficial for treating memory issues linked to depression.
[Transmission disequilibrium analysis of 1137-1140 Del GTGA frameshift mutation within the KCNN3 gene and schizophrenia based on family trios].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
August 2005
Objective: To investigate the relationship between 1137-1140 Del GTGA in exon 1 at KCNN3 gene and schizophrenia.
Methods: The study included 289 subjects (affected 107; unaffected 182) from 95 schizophrenic trios. All subjects were collected from Han Chinese in south China and genotyped for 1137-1140 Del GTGA in KCNN3 using PCR and restriction endonuclease Dde I.
Effects of chronic stress and phenytoin on the long-term potentiation (LTP) in rat hippocampal CA1 region.
Acta Biochim Biophys Sin (Shanghai)
May 2004
To investigate the changes of LTP in hippocampal CA1 region induced by chronic stress and the effect of phenytoin on them, thirty-two adult male Sprague-Dawley rats were randomly divided equally into four groups: control group, control-phenytoin group, stress-saline group and stress-phenytoin group. Isolated hippocampal slices of rats were used to observe the changes of long-term potentiation (LTP) in hippocampal CA1 field using electrophysiological technique. Amplitude of population spike (PS) and field excitatory postsynaptic potentials (fEPSPs) slope were used to indicate the changes of LTP.
View Article and Find Full Text PDFAim: To investigate the effects of phenytoin (DPH) on morphological and structural changes of pyramidal neurons in hippocampal CA3 of rats induced by chronic stress.
Methods: Using Nissl staining, Golgi staining, and electron microscope, the morphology and structure of pyramidal neurons in hippocampal CA3 of rats were observed.
Results: Chronic stress resulted in loss of hippocampal CA3 pyramidal neuron from 39+/-4 to 35+/-4, shortening of total length of apical dendrite (from 196 microm+/-35 microm to 156 microm+/-33 microm, P<0.