Publications by authors named "Chong-Shan Lv"
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer's disease (AD). Aberrations in GABAergic function and the excitatory/inhibitory (E/I) balance within the olfactory bulb (OB) have been implicated in olfactory impairment during the initial stages of AD. While the neuregulin 1 (NRG1)/ErbB4 signaling pathway is known to regulate GABAergic transmission in the brain and is associated with various neuropsychiatric disorders, its specific role in early AD-related olfactory impairment remains incompletely understood.
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- Alzheimer's disease (AD) is difficult to diagnose early, but retinal damage may indicate its onset before cognitive decline occurs.
- Salvianolic acid B (Sal B), derived from a traditional Chinese herb, shows potential in treating early-stage AD and retinopathy.
- In a study with 5×FAD mice, Sal B treatment improved retinal function and structure, suggesting it could help address early symptoms of AD by reducing harmful protein buildup and inflammation.
Article Synopsis
- Olfactory dysfunction is one of the first signs of Parkinson's disease, linked to α-synuclein accumulation in the olfactory bulb.
- Research on SNCA-A53T mice revealed that while their motor skills remained unaffected, their ability to detect and differentiate odors was impaired due to abnormal signaling in the olfactory bulb.
- The study found that targeting GABA signaling with tiagabine improved olfactory function, suggesting a new approach for diagnosing and treating early-stage Parkinson's disease.
Objective: The aim of this study was to explore potential immunoregulatory mechanisms underlying the suppressive effect on atherosclerosis of QiShenYiQi pill (QSYQ).
Methods And Results: Male ApoE mice were maintained on a Western-type diet and QSYQ treatment for eight weeks. Determination of atherosclerosis demonstrated that QSYQ attenuated plaque formation and decreased the level of blood low-density lipoproteins-cholesterol.