Publications by authors named "Chong-Qi Sun"
Navigating the labyrinth of long non-coding RNAs in colorectal cancer: From chemoresistance to autophagy.
World J Gastrointest Oncol
August 2024
Long non-coding RNAs (lncRNAs), with transcript lengths exceeding 200 nucleotides and little or no protein-coding capacity, have been found to impact colorectal cancer (CRC) through various biological processes. LncRNA expression can regulate autophagy, which plays dual roles in the initiation and progression of cancers, including CRC. Abnormal expression of lncRNAs is associated with the emergence of chemoresistance.
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- CHK1-targeted cancer therapies can increase the risk of heart problems, especially when combined with gemcitabine, but the exact reasons for this are not well understood.
- The study used human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and mouse models to investigate the cardiotoxic effects caused by these treatments, finding that they led to mitochondrial damage and heart dysfunction.
- The research highlighted the importance of mitochondrial CHK1, which helps maintain mitochondrial function, and suggested that boosting levels of SIRT3 could be a promising strategy to protect against heart damage related to these cancer therapies.
Article Synopsis
- KLF16, a member of the Krüppel-like factor family, has been under-researched in gastric cancer (GC) despite its potential significance.
- The study found that KLF16 is highly expressed in GC tissues compared to normal tissues, correlating with aggressive tumor characteristics and poor patient prognosis.
- Knocking down KLF16 in GC cell lines reduced cell proliferation by altering key proteins, suggesting KLF16 could be a valuable target for new cancer therapies.