Publications by authors named "Chong-Fei Huang"
Article Synopsis
- Extrahepatic cholangiocarcinoma sarcoma is a very rare cancer type that features both epithelial and mesenchymal cells, making it difficult to study due to the lack of available cell lines.
- The primary aim of the research was to create and characterize a new cell line called CBC2T-2, utilizing various methods like STR testing, cloning assays, and tumorigenicity tests in mice to understand its properties and potential for therapeutic research.
- Results confirmed the authenticity of the CBC2T-2 line, revealing unique cellular characteristics including high proliferation, migratory and invasive abilities, and distinct chromosomal structures that can aid in further studies on cholangiocarcinoma sarcoma treatments.
Article Synopsis
- * This study focused on five cardiac glycosides extracted from plants, with lanatoside C (Lan C) identified as the most effective in inhibiting the growth and inducing apoptosis in CCA cells.
- * The mechanism of Lan C's anticancer activity involved increasing reactive oxygen species, altering mitochondrial potential, and modulating specific protein expressions, ultimately leading to reduced tumor growth without harming normal cells.
Associations between serum uric acid and hepatobiliary-pancreatic cancer: A cohort study.
World J Gastroenterol
November 2020
Background: Uric acid is the end product of purine metabolism. Previous studies have found that serum uric acid (SUA) levels are associated with the total cancer risk. However, due to the dual effect of uric acid on cancer, the relationship between the SUA levels and most specific-site cancer remains unclear.
View Article and Find Full Text PDFBackground: Chronic hepatitis B virus infection remains a major global public health problem. Peginterferon-alpha-2a (PEG-IFN) has direct antiviral and immunoregulatory effects, and it has become one of the first choice drugs for the treatment of chronic hepatitis B (CHB). Cytokines play an important role in immunity, and they directly inhibit viral replication and indirectly determine the predominant pattern of the host immune response.
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