ZTW-41, a Potent Indolizinoquinoline-5,12-Dione Derivative Against Drug-Resistant and Bacteria.

ZTW-41, an indolizinoquinoline-5,12-dione derivative, was investigated for antibacterial activity against Gram-positive bacteria, especially methicillin-resistant (MRSA). In our study, the MICs (minimum inhibitory concentrations) of ZTW-41 against MRSA (MRSA,  = 200), methicillin-sensitive (MSSA,  = 100), (,  = 32), and ( = 32) were 0.25, 0.

Protective role of 6-Hydroxy-1-H-Indazole in an MPTP-induced mouse model of Parkinson's disease.

This study aimed to explore the neuroprotective role of 6-hydroxy-1H-indazole on dopaminergic neurons in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD). Forty 12-week-old C57BL/6 male mice were were randomized divided into 4 groups. Mice were treated with 2mg/kg and 4mg/kg 6-hydroxy-1H-indazole (i.