Publications by authors named "Chong-Dong Liu"
Article Synopsis
- * Using various bioinformatics tools, the study found elevated levels of SLC30A1, SLC30A7, and SLC30A10 in cervical cancer tissues compared to normal ones, while SLC30A2 and SLC30A8 levels decreased.
- * High expression of certain SLC30 genes is linked to worse survival outcomes for cervical cancer patients and could offer insights for new diagnostic and therapeutic strategies.
Article Synopsis
- Preeclampsia (PE) is a serious pregnancy-related high blood pressure disorder, and early diagnosis is crucial, potentially aided by new diagnostic markers.
- Transthyretin (TTR) levels are lower in severe PE cases, and experiments on hypertensive pregnant rats showed that TTR treatment reversed high blood pressure and protein levels in urine.
- The study indicates that TTR could help improve placental health and cell function, suggesting it has potential as a new diagnostic marker for PE.
Article Synopsis
- Wall shear stress is crucial in the development of neointimal hyperplasia post-stent implantation, with higher shear stress linked to reduced hyperplasia.
- In a study involving male rabbits, the group with both stent implantation and arteriovenous fistula exhibited significantly higher wall shear stress and lower neointimal hyperplasia compared to the stent-only group.
- The findings suggest that increased wall shear stress helps regulate specific proteins related to vascular health, indicating potential therapeutic benefits in managing stent-related complications.
Background: Therapeutic neovascularization has some obstacles, such as it requires more than one proangiogenic factor, and these factors have short half-lives. To overcome these obstacles, combined delivery of granulocyte-colony stimulating factor (G-CSF), erythropoietin (EPO) and vascular endothelial growth factor (VEGF) using protein/dextran/poly (lactic-co-glycolic acid) (PLGA) sustained-release microspheres was proposed to promote neovascularization.
Methods: Dextran microparticles loaded with G-CSF, EPO or VEGF were prepared and encapsulated in PLGA microspheres to obtain protein-dextran-PLGA microspheres.
We hypothesize that the controlled delivery of vascular endothelial growth factor (VEGF) using a novel protein sustained-release system based on the combination of protein-loaded dextran microparticles and PLGA microspheres could be useful to achieve mature vessel formation in a rat hind-limb ischemic model. VEGF-loaded dextran microparticles were fabricated and then encapsulated into poly(lactic-co-glycolic acid) (PLGA) microspheres to prepare VEGF-dextran-PLGA microspheres. The release behavior and bioactivity in promoting endothelial cell proliferation of VEGF from PLGA microspheres were monitored in vitro.
View Article and Find Full Text PDFBackground: The molecular mechanisms underlying the endometriosis are still not completely understood. In order to test the hypothesis that the approaches in phosphoproteomics might contribute to the identification of key biomarkers to assess disease pathogenesis and drug targets, we carried out a phosphoproteomics analysis of human endometrium.
Methods: A large-scale differential phosphoproteome analysis, using peptide enrichment of titanium dioxide purify and sequential elution from immobilized metal affinity chromatography with linear trap quadrupole-tandem mass spectrometry, was performed in endometrium tissues from 8 women with or without endometriosis.
Objective: To investigate the necessity, safety and efficacy of transobturator tension-free vaginal tape (TVT-O) for treatment of stress urinary incontinence (SUI) during transvaginal corrective operation of pelvic organ prolapse (POP).
Methods: From Jan. 2005 to Dec.
Background: Venous thromboembolism is known to be an important social and health care problem because of its high incidence among patients who undergo surgery. Studies on the mechanical prophylaxis of thromboembolism after gynaecological pelvic surgery are few. The aim of our study was to evaluate the effect of mechanical thromboembolism prophylaxis after gynaecological pelvic surgery using a combination of graduated compression stockings (GCS) and intermittent pneumatic compression (IPC) or GCS alone.
View Article and Find Full Text PDF[Prospective investigation of postoperative lower extremity deep venous thrombosis in gynecological procedures].
Zhonghua Fu Chan Ke Za Zhi
February 2006
Objective: To investigate the morbidity, relevant factors and diagnostic methods of lower extremity deep venous thrombosis (LEDVT) after gynecological pelvic surgeries.
Methods: A prospective study was carried out investigating the morbidity, characteristics, risk factors, the coagulation function changes and diagnostic methods of LEDVT post-gynecological pelvic operations in 141 cases. Platelet, prothrombin time, activated partial thromboplastin time, fibrinogen, thrombin time, D-dimer, antithrombin-III, tissue plasminogen activator, plasminogen activator inhibitor were measured within 1 week before surgeries, 48 hours and 5 - 7 days post-surgeries respectively.