Clinical effect of surgical correction for nasal pathology on the treatment of obstructive sleep apnea syndrome.

Objectives: This study aimed to evaluate the hypothesis that relief of nasal obstruction in subjects with obstructive sleep apnea (OSA) would lead to reduce OSA severity and to discuss the available evidence on the clinical efficacy of nasal surgery as a treatment modality for OSA.

Study Design: Twenty-five subjects who had reduced patency of nasal cavity and narrowing of retroglossal or retropalatal airways were diagnosed with OSA and underwent nasal surgery, such as septoplasty or turbinoplasty to correct nasal pathologies. The effect of the surgery on nasal patency was quantified by measuring minimal cross-sectional area (MCA) using acoustic rhinometry.

Clinical usefulness of watch-PAT for assessing the surgical results of obstructive sleep apnea syndrome.

Objective: This study aimed to assess the accuracy and clinical efficacy of a wrist-worn device that is based on peripheral arterial tonometry (watch-PAT) to evaluate the surgical results of obstructive sleep apnea (OSA) syndrome subjects.

Study Design And Method: Thirty-five subjects who were diagnosed with OSA and underwent sleep surgeries such as septoplasty, tonsillectomy, or uvuloplasty to correct their airway collapse, participated in this study; the watch-PAT-derived respiratory disturbance index (RDI), apnea and hypopnea index (AHI), lowest oxygen saturation, and valid sleep time were measured after the sleep surgery.

Results: The present study showed that RDI (32.

Reactive oxygen species induce antiviral innate immune response through IFN-λ regulation in human nasal epithelial cells.

This study sought to explore the role of the IFN-related innate immune responses (IFN-β and IFN-λ) and of reactive oxygen species (ROS) after influenza A virus (IAV) infection for antiviral innate immune activity in normal human nasal epithelial (NHNE) cells that are highly exposed to IAV. Passage-2 NHNE cells were inoculated with the IAV WSN/33 for 1, 2, and 3 days to assess the capacity of IFN and the relationship between ROS generation and IFN-λ secretion for controlling IAV infection. Viral titers and IAV mRNA levels increased after infection.

Analyzing serum eosinophil cationic protein in the clinical assessment of chronic rhinosinusitis.

Background: Eosinophil cationic protein (ECP) is a major granule-derived protein with cytotoxic activity found in eosinophils and has been known as a useful marker of allergic inflammation. In this study, we assessed the clinical significance of ECP in chronic inflammation of the nasal mucosa by evaluating the relationship between eosinophil activity and serum ECP concentration in a cohort of subjects with or without chronic rhinosinusitis (CRS) and allergic rhinitis (AR).

Methods: We retrospectively reviewed the medical records of 492 subjects and analyzed eosinophil percentage in nasal smears, serum eosinophil counts, serum ECP concentrations, symptom scores, CT scores, the size of nasal polyp, and recurrence of CRS at follow-up.

Therapeutic effects of carbogen inhalation and lipo-prostaglandin E1 in sudden hearing loss.

Purpose: Vascular disorders and viral infections are considered the main causes of sudden hearing loss (SHL), although its pathogenesis remain unclear. Treatments include carbogen inhalation and lipo-prostaglandin E1 (lipo-PGE1), both of which have circulation-enhancing effects. We investigated the effectiveness of carbogen inhalation and lipo-PGE1 in SHL.

When should retained Paparella type I tympanostomy tubes be removed in asymptomatic children?

Objectives: Tympanostomy tubes are routinely used for the treatment of otitis media with effusion (OME). There is no definite consensus on the optimal length of the intubation period and the timing of tube removal. This study was designed to determine the appropriate time for tympanostomy tube removal in asymptomatic patients of preschool age.

The effect of early canalith repositioning on benign paroxysmal positional vertigo on recurrence.

Objectives: Benign paroxysmal positional vertigo (BPPV) can be treated using a simple repositioning maneuver. This study demonstrates the effects of early repositioning therapy in patients with BPPV, especially with regard to recurrence.

Methods: We enrolled 138 consecutive patients who had been diagnosed with BPPV in the emergency rooms and ENT out-patient clinics of Chung-Ang University Hospital and Samyook Medical Center from January to June 2009.

Surgical management of labyrinthine fistula in chronic otitis media with cholesteatoma.

Objective: To present the surgical outcomes of complete removal of the matrix of labyrinthine fistulas in a large series of middle ear cholesteatomas.

Patients And Methods: This is a retrospective study. We analyzed 38 of 778 patients who were operated on for cholesteatoma and were proved to have labyrinthine fistula from 1991 to 2007.

Nighttime facial pain induced by myxoma of the maxillary sinus: a case report.

Myxomas of the maxillary sinus are uncommon benign tumors arising from the primitive mesenchyme. They may be related to dental malformations or missing teeth but may also occur without any abnormalities. They usually result in facial deformity manifested by slow, painless bony expansion.

Spontaneous pneumocephalus associated with pneumocele of the frontal sinus.

Background: Pneumoceles of the paranasal sinuses are a very rare condition; characterized by a distended air-filled paranasal sinus extending beyond the margins of the paranasal bone, with bony defects and extension of air into the surrounding soft tissues. Also, spontaneous pneumo-cephalus is a rare condition which represented only 0.6% in the largest reported series of pneumocephalus.