Unexpected 18-Fold Overlapped Feathery Fermi Pockets in Typical Thermoelectric Bi_{0.5}Sb_{1.5}Te_{3}.

Bi_{0.5}Sb_{1.5}Te_{3} is the most widely used p-type commercial thermoelectric materials over six decades, yet its complex electronic structure remains uncertain especially in band degeneracy and k_{z} dispersions.

Unveiling the photophysical mechanisms in low-dimensional Zn/Cu-based metal halides.

The intriguing photophysical mechanisms of low-dimensional metal-halide hybrids are still elusive. This study investigates the optical properties and photophysical mechanisms of (CHN)ZnBr and (CHN)CuBr crystals. The former shows variable emission due to π-conjugation and intramolecular halogen-hydrogen bonds, while the latter exhibits a broad, temperature-sensitive emission from self-trapped excitons.

[Banxia Xiexin Decoction suppresses malignant phenotypes of colon cancer cells via PARG/PARP1/NF-κB signaling pathway].

This study aims to delve into the influences and underlying mechanisms of Banxia Xiexin Decoction(BXD) on the proliferation, apoptosis, invasion, and migration of colon cancer cells. Firstly, the components of BXD in blood were identified by UPLC-MS/MS, and subsequently the content of these components were determined by HPLC. Then, different concentrations of BXD were used to treat both the normal intestinal epithelial cells(NCM460) and the colon cancer cells(HT29 and HCT116).

Extremely low lattice thermal conductivity in light-element solid materials.

Lattice thermal conductivity ( ) is of great importance in basic sciences and in energy conversion applications. However, low- crystalline materials have only been obtained from heavy elements, which typically exhibit poor stability and possible toxicity. Thus, low- materials composed of light elements should be explored.

Olink Profiling of Intestinal Tissue Identifies Novel Biomarkers For Colorectal Cancer.

Comprehensive protein profiling in intestinal tissues provides detailed information about the pathogenesis of colorectal cancer (CRC). This study quantified the expression levels of 92 oncology-related proteins in tumors, paired para-carcinoma tissues, and remote normal tissues from a cohort of 52 CRC patients utilizing the Olink technology. The proteomic profile of normal tissues closely resembled that of para-carcinoma tissues while distinctly differing from that of tumors.

Direct and indirect effects of estrogens, androgens and intestinal microbiota on colorectal cancer.

Sex differences in colorectal cancer (CRC) has received considerable research attention recently, particularly regarding the influence of sex hormones and the intestinal microbiota. Estrogen, at the genetic and epigenetic levels, directly inhibits CRC cell proliferation by enhancing DNA mismatch repair, regulating miRNAs, blocking the cell cycle, and modulating ion channels. However, estradiol's activation of GPER promotes oncogene expression.

Intratumoral microbiota in colorectal cancer: focus on specific distribution and potential mechanisms.

Colorectal cancer (CRC) is one of the most prevalent and lethal malignant tumors globally, posing significant health risks and societal burdens. Recently, advancements in next-generation sequencing technology have identified CRC intratumoral microbiota, thereby opening up novel avenues for further research. This review synthesizes the current advancements in CRC intratumoral microbiota and their impact on CRC progression and discusses the disparities in the relative abundance and community composition of CRC intratumoral microbiota across various colorectal tumors based on their anatomical location and molecular subtypes, as well as the tumor stages, and spatial tumor distribution.

Hole Polaron-Mediated Suppression of Electron-Hole Recombination Triggers Efficient Photocatalytic Nitrogen Fixation.

In the pursuit of successful photocatalytic transformations, challenges persist due to limitations in charge carrier utilization and transfer efficiency, which stemming from rapid recombination. Overcoming these limitations necessitates the exploration of novel mechanisms that enhance the effective separation of photogenerated electron-hole pairs. Herein, deviating from the conventional approach of enhancing carrier migration to separate photogenerated charges and extend their lifetime, the proposal is to directly prevent the recombination of photogenerated electrons and holes by forming hole polarons.

17β-estradiol in colorectal cancer: friend or foe?

Colorectal cancer (CRC) is a common gastrointestinal malignancy with higher incidence and mortality rates in men compared to women, potentially due to the effects of estrogen signaling. There is substantial evidence supporting the significant role of 17β-Estradiol (E2) in reducing CRC risk in females, although this perspective remains debated. E2 has been demonstrated to inhibit CRC cell proliferation and migration at the cellular level by enhancing DNA mismatch repair, modulating key gene expression, triggering cell cycle arrest, and reducing activity of migration factors.

High-Entropy Strategy to Achieve Electronic Band Convergence for High-Performance Thermoelectrics.

Multiband convergence has attracted significant interest due to its positive effects on further improving thermoelectric performance. However, the current research mainly focuses on two- or three-band convergence in lead chalcogenides through doping and alloying. Therefore, exploring a new strategy to facilitate more-band convergence has instructive significance and practical value in thermoelectric research.

Sex differences in colorectal cancer: with a focus on sex hormone-gut microbiome axis.

Sexual dimorphism has been observed in the incidence and prognosis of colorectal cancer (CRC), with men generally exhibiting a slightly higher incidence than women. Research suggests that this difference may be attributed to variations in sex steroid hormone levels and the gut microbiome. The gut microbiome in CRC shows variations in composition and function between the sexes, leading to the concept of 'microgenderome' and 'sex hormone-gut microbiome axis.

Multiple roles of baicalin and baicalein in the regulation of colorectal cancer.

The prevalence of colorectal cancer is increasing worldwide, and despite advances in treatment, colorectal cancer (CRC) remains in the top three for mortality due to several issues, including drug resistance and low efficiency. There is increasing evidence that baicalin and baicalein, novel small molecule inhibitor extracts of the Chinese herb Scutellaria baicalensis, have better anti-colorectal cancer effects and are less likely to induce drug resistance in cancer cells. The present review article explains the anti-proliferative properties of baicalin and baicalein in the context of against CRC.

Integrated network pharmacology, metabolomics, and transcriptomics of Huanglian-Hongqu herb pair in non-alcoholic fatty liver disease.

Ethnopharmacological Relevance: The Huanglian-Hongqu herb pair (HH) is a synergistic drug combination used to treat non-alcoholic fatty liver disease (NAFLD). However, the molecular mechanism underlying the therapeuticeffects of HH requires further elucidation.

Aim Of The Study: The present study explored the potential mechanism of HH in treating NAFLD.

Causal linkage between type 2 diabetes mellitus and inflammatory bowel disease: an integrated Mendelian randomization study and bioinformatics analysis.

Background: Observational studies have indicated associations between type 2 diabetes mellitus (T2DM) and both colorectal cancer (CRC) and inflammatory bowel disease (IBD). However, the underlying causality and biological mechanisms between these associations remains unclear.

Methods: We conducted a bidirectional Mendelian randomization (MR) analysis employing summary statistics from genome-wide association studies involving European individuals.

Efficacy and safety of traditional plant-based medicines for preventing chronic oxaliplatin-induced peripheral neurotoxicity in patients with colorectal cancer: A systematic review and meta-analysis with core herb contribution.

Ethnopharmacological Relevance: Traditional plant-based medicines (TMs) have been widely used to prevent chronic oxaliplatin-induced peripheral neurotoxicity (OIPN). However, the prevention and safety of TMs for chronic OIPN remain ambiguous. Furthermore, diverse TM prescriptions and complicated components limit in-depth research on the mechanisms of TMs.

Mitochondrial fusion-fission dynamics and its involvement in colorectal cancer.

The incidence and mortality rates of colorectal cancer have elevated its status as a significant public health concern. Recent research has elucidated the crucial role of mitochondrial fusion-fission dynamics in the initiation and progression of colorectal cancer. Elevated mitochondrial fission or fusion activity can contribute to the metabolic reprogramming of tumor cells, thereby activating oncogenic pathways that drive cell proliferation, invasion, migration, and drug resistance.

Interlayer Phonon Coupling from Heavy and Light Sublayers in a Natural Van der Waals Superlattice.

Layered compounds characterized by van der Waals gaps are often associated with relatively weak interlayer particle interactions. However, in specific scenarios, these seemingly feeble forces can exert an impact on interlayer interactions through subtle energy fluctuations, which can give rise to a diverse range of physical and chemical properties, particularly intriguing in the context of thermal transport. In this study, taking a natural superlattice composed of alternately stacked PbS and SnS sublayers as a model, we proposed that in a superlattice, there is strong hybridization between acoustic phonons of heavy sublayers and optical phonons of light sublayers.

Recent Advancements in Electrochemical Hydrogen Production via Hybrid Water Splitting.

As one of the most promising approaches to producing high-purity hydrogen (H ), electrochemical water splitting powered by the renewable energy sources such as solar, wind, and hydroelectric power has attracted considerable interest over the past decade. However, the water electrolysis process is seriously hampered by the sluggish electrode reaction kinetics, especially the four-electron oxygen evolution reaction at the anode side, which induces a high reaction overpotential. Currently, the emerging hybrid electrochemical water splitting strategy is proposed by integrating thermodynamically favorable electro-oxidation reactions with hydrogen evolution reaction at the cathode, providing a new opportunity for energy-efficient H2 production.

Dual-Plasmon Resonance Coupling Promoting Directional Photosynthesis of Nitrate from Air.

Photocatalysis, particularly plasmon-mediated photocatalysis, offers a green and sustainable approach for direct nitrogen oxidation into nitrate under ambient conditions. However, the unsatisfactory photocatalytic efficiency caused by the limited localized electromagnetic field enhancement and short hot carrier lifetime of traditional plasmonic catalysts is a stumbling block to the large-scale application of plasmon photocatalytic technology. Herein, we design and demonstrate the dual-plasmonic heterojunction (Bi/Cs WO ) achieves efficient and selective photocatalytic N oxidation.

Electron transfer bridge inducing polarization of nitrogen molecules for enhanced photocatalytic nitrogen fixation.

Ammonia (NH) plays a crucial role in the production of fertilizers, medicines, fibers, , which are closely relevant to the development of human society. However, the inert and nonpolar properties of NN seriously hinder artificial nitrogen fixation under mild conditions. Herein, we introduce a novel strategy to enhance the photocatalytic efficiency of N fixation through the directional polarization of N by rare earth metal atoms, which act as a local "electron transfer bridge.

Tong-Xie-Yao-Fang promotes dendritic cells maturation and retards tumor growth in colorectal cancer mice with chronic restraint stress.

Ethnopharmacological Relevance: Depression is one of the important risk factors that accelerate the progression of colorectal cancer (CRC). Tong-Xie-Yao-Fang (TXYF) is a widely used classical formula for treating psychiatric-related intestinal diseases in traditional Chinese medicine, that is composed of four different herbs: Atractylodes macrocephala Koidz. (Baizhu), Paeonia lactiflora Pall.

Directional Shunting of Photogenerated Carriers in POM@MOF for Promoting Nitrogen Adsorption and Oxidation.

The efficient catalysis of nitrogen (N ) into high-value N-containing products plays a crucial role in the N economic cycle. However, weak N adsorption and invalid N activation remain two major bottlenecks in rate-determining steps, leading to low N fixation performance. Herein, an effective dual active sites photocatalyst of polyoxometalates (POMs)-based metal-organic frameworks (MOFs) is highlighted via altering coordination microenvironment and inducing directional shunting of photogenerated carriers to facilitate N /catalyst interaction and enhance oxidation performance.

Realizing Plain Optimization of the Thermoelectric Properties in BiCuSeO Oxide via Self-Substitution-Induced Lattice Dislocations.

Seeking new strategies to tune the intrinsic defect and optimize the thermoelectric performance via no or less use of external doped elements (i.e., plain optimization) is an important method to realize the sustainable development of thermoelectric materials.