Adjuvant therapy for HER2 positive pT1a-b pN0 breast cancer: A single center cohort study.

Deciding if patients with small (≤1 cm), node-negative, human epidermal growth factor receptor 2 (HER2) positive breast cancer should receive adjuvant systemic therapy remains a challenge. No randomized clinical trials have examined the efficacy of trastuzumab in this setting. This prospective observational study aimed to investigate the choice of adjuvant systemic therapy in clinical practice in China.

A Fusion Algorithm of Object Detection and Tracking for Unmanned Surface Vehicles.

To provide reliable input for obstacle avoidance and decision-making, unmanned surface vehicles (USV) need to have the function of sensing the position of other USV targets in the process of cooperation and confrontation. Due to the small size of the target and the interference of the water and sky background, the current algorithms are prone to missed detection and drift problems when detecting and tracking USV. Therefore, in this paper, we propose a fusion algorithm of detection and tracking for USV targets.

Long non-coding RNA PVT1-mediated miR-543/SERPINI1 axis plays a key role in the regulatory mechanism of ovarian cancer.

Purpose: To investigate the regulation mechanism of long non-coding RNA (lncRNA) plasmocytoma variant translocation 1 (PVT1) in ovarian cancer (OC).

Methods: The levels of PVT1, microRNA (miR)-543, serpin peptidase inhibitor-clade I (neuroserpin)-member 1 (SERPINI1) in OC tissues and OVCAR-3, A2780, TOV-112D of OC cell lines were detected by quantitative real-time PCR (qRT-PCR) and Western Blot (WB). Cell proliferation, migration, invasion, apoptosis and the regulatory relationship between genes and target genes were analyzed by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), Transwell, flow cytometry and dual luciferase reporter (DLR).

Fabrication of Hollow CoP/TiO Heterostructures for Enhanced Oxygen Evolution Reaction.

Transition-metal phosphides have flourished as promising candidates for oxygen evolution reaction (OER) electrocatalysts. Herein, it is demonstrated that the electrocatalytic OER performance of CoP can be greatly improved by constructing a hybrid CoP/TiO heterostructure. The CoP/TiO heterostructure is fabricated using metal-organic framework nanocrystals as templates, which leads to unique hollow structures and uniformly distributed CoP nanoparticles on TiO .

Synergistic Effect of Co-Ni Hybrid Phosphide Nanocages for Ultrahigh Capacity Fast Energy Storage.

Rational design of metal compounds in terms of the structure/morphology and chemical composition is essential to achieve desirable electrochemical performances for fast energy storage because of the synergistic effect between different elements and the structure effect. Here, an approach is presented to facilely fabricate mixed-metal compounds including hydroxides, phosphides, sulfides, oxides, and selenides with well-defined hollow nanocage structure using metal-organic framework nanocrystals as sacrificial precursors. Among the as-synthesized samples, the porous nanocage structure, synergistic effect of mixed metals, and unique phosphide composition endow nickel cobalt bimetallic phosphide (NiCo-P) nanocages with outstanding performance as a battery-type Faradaic electrode material for fast energy storage, with ultrahigh specific capacity of 894 C g at 1 A g and excellent rate capability, surpassing most of the reported metal compounds.

Growth and optoelectronic application of CsPbBr thin films deposited by pulsed-laser deposition.

All-inorganic perovskite CsPbBr thin films have been prepared on Si (100) substrate by a pulsed-laser deposition (PLD) technique, and the morphology, structure, absorbance, and photoluminescence properties of CsPbBr thin films are investigated. A photodetector based on CsPbBr/n-Si heterojunction has been fabricated, and the performances of the device are characterized. The heterojunction photodetector exhibits diode-like rectifying behavior, and the photocurrent-to-dark-current ratio and peak responsivity of the heterojunction are approximately 168.

Operando Investigation into Dynamic Evolution of Cathode-Electrolyte Interfaces in a Li-Ion Battery.

While Li-ion battery cathode-electrolyte interfaces (CEIs) have been extensively investigated in recent decades, accurately identifying the chemical nature and tracking the dynamics of the CEIs during electrochemical cycling still remain a grand challenge. Here we report our findings in the investigation into the dynamic evolution of the interface between a LiNiCoMnO (LNMC) cathode and an ethylene carbonate/dimethyl carbonate (EC/DMC)-based electrolyte using surface-enhanced Raman spectroscopy (SERS) performed on a model cell under typical battery operating conditions. In particular, the strong SERS activity provided by a monolayer of Au nanocubes deposited on a model LNMC electrode (additive-free) enables quasi-quantitative assessment of the CEI evolution during cycling, proving information vital to revealing the dynamics of the species adsorbed on the LNMC surface as a function of cell potential.

Long noncoding RNA SNHG15 serves as an oncogene and predicts poor prognosis in epithelial ovarian cancer.

Objective: This study aims to investigate the functional role of long noncoding RNA SNHG15 in epithelial ovarian cancer (EOC).

Materials And Methods: The expression of SNHG15 was measured in EOC cells and tissues using qRT-PCR. The correlation of SNHG15 expression and the clinicopathological characters was statistically analyzed.

Puffing Up Energetic Metal-Organic Frameworks to Large Carbon Networks with Hierarchical Porosity and Atomically Dispersed Metal Sites.

Large carbon networks featuring hierarchical pores and atomically dispersed metal sites (ADMSs) are ideal materials for energy storage and conversion due to the spatially continuous conductive networks and highly active ADMSs. However, it is a challenge to synthesize such ADMS-decorated carbon networks. Here, an innovative fusion-foaming methodology is presented in which energetic metal-organic framework (EMOF) nanoparticles are puffed up to submillimeter-scaled ADMS-decorated carbon networks via a one-step pyrolysis.

Tuning Expanded Pores in Metal-Organic Frameworks for Selective Capture and Catalytic Conversion of Carbon Dioxide.

Three Co-based isostructural MOF-74-III materials with expanded pores are synthesized, with varied extent of fused benzene rings onto sidechain of same-length ligands to finely tune the pore sizes to 2.6, 2.4, and 2.

Highly Dispersed Co-B/N Codoped Carbon Nanospheres on Graphene for Synergistic Effects as Bifunctional Oxygen Electrocatalysts.

Oxygen reduction and evolution reactions as two important electrochemical energy conversion processes in metal-air battery devices have aroused widespread concern. However, synthesis of low-cost non-noble metal-based bifunctional high-performance electrocatalysts is still a great challenge. In this work, we report on the design and synthesis of a novel Co-B/N codoped carbon with core-shell-structured nanoparticles aligned on graphene nanosheets (denoted as CoTIB-C/G) derived from cobalt tetrakis(1-imidazolyl)borate (CoTIB) and graphene oxide hybrid template.

Tuning the Catalytic Activity of Ir@Pt Nanoparticles Through Controlling Ir Core Size on Cathode Performance for PEM Fuel Cell Application.

Pulse electrochemically synthesis of a series of core-shell structured Ir@Pt/C catalysts in cathode catalysts layer are achieved to fabricate membrane electrode assemblies (MEA) with cathode ultra-low Pt loading. The single cell performance of the MEAs in a H/air PEMFC greatly rely on the sizes of the Ir core nanoparticle, and the optimum activity occurs with Ir core size of 4.1 nm.

"One-for-All" Strategy in Fast Energy Storage: Production of Pillared MOF Nanorod-Templated Positive/Negative Electrodes for the Application of High-Performance Hybrid Supercapacitor.

Currently, metal-organic frameworks (MOFs) are intensively studied as active materials for electrochemical energy storage applications due to their tunable structure and exceptional porosities. Among them, water stable pillared MOFs with dual ligands have been reported to exhibit high supercapacitor (SC) performance. Herein, the "One-for-All" strategy is applied to synthesize both positive and negative electrodes of a hybrid SC (HSC) from a single pillared MOF.

Atomically Dispersed Metal Sites in MOF-Based Materials for Electrocatalytic and Photocatalytic Energy Conversion.

Metal sites play an essential role in both electrocatalytic and photocatalytic energy conversion. The highly ordered arrangements of the organic linkers and metal nodes as well as the well-defined pore structures of metal-organic frameworks (MOFs) make them ideal substrates to support atomically dispersed metal sites (ADMSs) located in their metal nodes, linkers, and pores. Porous carbon materials doped with ADMSs can be derived from these ADMS-incorporating MOF precursors through controlled treatments.

A Universal Strategy for Hollow Metal Oxide Nanoparticles Encapsulated into B/N Co-Doped Graphitic Nanotubes as High-Performance Lithium-Ion Battery Anodes.

Yolk-shell nanostructures have received great attention for boosting the performance of lithium-ion batteries because of their obvious advantages in solving the problems associated with large volume change, low conductivity, and short diffusion path for Li ion transport. A universal strategy for making hollow transition metal oxide (TMO) nanoparticles (NPs) encapsulated into B, N co-doped graphitic nanotubes (TMO@BNG (TMO = CoO, Ni O , Mn O ) through combining pyrolysis with an oxidation method is reported herein. The as-made TMO@BNG exhibits the TMO-dependent lithium-ion storage ability, in which CoO@BNG nanotubes exhibit highest lithium-ion storage capacity of 1554 mA h g at the current density of 96 mA g , good rate ability (410 mA h g at 1.

Pristine Metal-Organic Frameworks and their Composites for Energy Storage and Conversion.

Metal-organic frameworks (MOFs), a new class of crystalline porous organic-inorganic hybrid materials, have recently attracted increasing interest in the field of energy storage and conversion. Herein, recent progress of MOFs and MOF composites for energy storage and conversion applications, including photochemical and electrochemical fuel production (hydrogen production and CO reduction), water oxidation, supercapacitors, and Li-based batteries (Li-ion, Li-S, and Li-O batteries), is summarized. Typical development strategies (e.

Kinetic-Controlled Formation of Bimetallic Metal-Organic Framework Hybrid Structures.

Heterometallic metal-organic frameworks (MOFs) are constructed from two or more kinds of metal ions, while still remaining their original topologies. Due to distinct reaction kinetics during MOF formation, partial distribution of different metals within a single MOF crystal can lead to sophisticated heterogeneous nanostructures. Here, this study reports an investigation of reaction kinetics for different metal ions in a bimetallic MOF system, the ZIF-8/67 (M(2-mIM) , M = Zn for ZIF-8, and Co for ZIF-67, 2-mIM = 2-methylimidazole), by in situ optical method.

Luminescence Properties and Mechanisms of CuI Thin Films Fabricated by Vapor Iodization of Copper Films.

Copper iodide (CuI) thin films were grown on Si(100) substrates using a copper film iodination reaction method. It was found that γ-CuI films have a uniform and dense microstructure with (111)-orientation. Transmission spectra indicated that CuI thin films have an average transmittance of about 60% in the visible range and the optical band gap is 3.

High-Performance Energy Storage and Conversion Materials Derived from a Single Metal-Organic Framework/Graphene Aerogel Composite.

Metal oxides and carbon-based materials are the most promising electrode materials for a wide range of low-cost and highly efficient energy storage and conversion devices. Creating unique nanostructures of metal oxides and carbon materials is imperative to the development of a new generation of electrodes with high energy and power density. Here we report our findings in the development of a novel graphene aerogel assisted method for preparation of metal oxide nanoparticles (NPs) derived from bulk MOFs (Co-based MOF, Co(mIM) (mIM = 2-methylimidazole).

Improvement of UV electroluminescence of n-ZnO/p-GaN heterojunction LED by ZnS interlayer.

n-ZnO/p-GaN heterojunction light emitting diodes with different interfacial layers were fabricated by pulsed laser deposition. The electroluminescence (EL) spectra of the n-ZnO/p-GaN diodes display a broad blue-violet emission centered at 430 nm, whereas the n-ZnO/ZnS/p-GaN and n-ZnO/AlN/p-GaN devices exhibit ultraviolet (UV) emission. Compared with the AlN interlayer, which is blocking both electron and hole at hetero-interface, the utilization of ZnS as intermediate layer can lower the barrier height for holes and keep an effective blocking for electron.

[Investigation of luminescence mechanism of hybrid MEH-PPV/ SiO2 and super liner characteristic of amorphous SiO2].

For electricity induced luminescence of thin film, the heterojunction luminescence devices were produced by compounding the organic polymer of MEH-PPV and inorganic semiconductor SiO2. Utilizing the super liner characteristic of SiO2 as acceleration, multiplication and ionization, the solid-state cathodoluminescence was realized. The obvious feature of electroluminescence in the luminescence device with ITO/SiO2/MEH-PPV/SiO2/Al is that it has two spectral bands.