Publications by authors named "Chong Mian-Yoon"
Parkinson's disease (PD) is a debilitating neurodegenerative disease with a relentlessly progressive course of illness. This study aimed to assess the dyadic dynamics of benefit finding (BF), demoralization, and stigma on the depression severity of PD patients and their caregivers. This study used a cross-sectional design with purposive sampling.
View Article and Find Full Text PDFBackground: As clinical practices with lithium salts for patients diagnosed with bipolar disorder (BD) are poorly documented in Asia, we studied the prevalence and clinical correlates of lithium use there to support international comparisons.
Methods: We conducted a cross-sectional study of use and dosing of lithium salts for BD patients across 13 Asian sites and evaluated bivariate relationships of lithium treatment with clinical correlates followed by multivariate logistic regression modeling.
Results: In a total of 2139 BD participants (52.
Background: Schizophrenia patients endure high risks of metabolic syndrome and related cardiovascular mortality. Evidence on comparing detective power among atherogenic indices of the metabolic syndrome in schizophrenia patients with antipsychotics treatment is still lacking.
Method: We recruited 128 schizophrenia patients and collected blood samples to determine plasma levels of fasting glucose, total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol.
Article Synopsis
- This study analyzes the prescription patterns of mood stabilizers, primarily used for bipolar disorder, across 10 Asian countries and highlights their use in treating other psychiatric conditions.
- It found that more than half of the patients had schizophrenia or similar disorders, and symptoms like irritability and aggression were common targets for treatment.
- The results suggest that while mood stabilizers are frequently used off-label for various psychiatric diagnoses, the effectiveness and justification of this practice need further research.
Background: Pharmacoepidemiological studies of clozapine use to treat bipolar disorder (BD), especially in Asia, are rare, although they can provide insights into associated clinical characteristics and support international comparisons of indications and drug dosing.
Methods: We examined the prevalence and clinical correlates of clozapine treatment for BD in 13 Asian countries and regions (China, Hong Kong SAR, India, Indonesia, Japan, Korea, Malaysia, Myanmar, Pakistan, Singapore, Sri Lanka, Taiwan, and Thailand) within an Asian Prescription Patterns Research Consortium. We compared BD patients treated with clozapine or not in initial bivariate comparisons followed by multivariable logistic regression modeling.
Introduction: Drug-induced extrapyramidal syndrome (EPS) remains a major problem in clinical psychiatry. This study aimed to examine the factor structure of drug-induced extrapyramidal symptoms observed in patients with schizophrenia and assessed using the Drug-Induced Extrapyramidal Symptoms Scale (DIEPSS).
Methods: The participants were 1478 patients with a diagnosis of schizophrenia whose EPS was assessed using the DIEPSS in India, Indonesia, Japan, Malaysia, and Taiwan in the 2016 REAP AP-4 study.
Psychotic symptoms are rarely concurrent with the clinical manifestations of depression. Additionally, whether psychotic major depression is a subtype of major depression or a clinical syndrome distinct from non-psychotic major depression remains controversial. Using data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants, we developed a machine-learning-algorithm-based prediction model for concurrent psychotic symptoms in patients with depressive disorders.
View Article and Find Full Text PDFAims: Schizophrenia is a major mental disorder with a wide range of psychiatric symptoms. This study explored the structure of psychiatric symptoms of schizophrenia using network analysis in a large representative Asian sample based on a survey of clinical features and treatment used in schizophrenia patients across 15 countries/territories in Asia.
Methods: Data on the demographic characteristics and psychiatric symptoms in schizophrenia patients were extracted from the dataset of the fourth Research on Asia Psychotropic Prescription for Antipsychotics (REAP-AP) project.
Article Synopsis
- Clozapine combined with electroconvulsive therapy (ECT) is an effective treatment for patients with schizophrenia who do not respond to standard therapies, particularly in Asian populations.
- A study utilized machine learning techniques, specifically random forest and LASSO models, to create a prediction model identifying key variables that influence the success of this treatment combination, with significant results from a sample of 3,744 patients.
- Findings highlighted important factors such as inpatient status, BMI, and duration of illness, enabling a more tailored approach in treating schizophrenia through personalized medicine.
Article Synopsis
- * Conducted across 13 Asian countries, the research found that out of 1,647 participants, 13.1% were on high doses, with factors like younger age, male sex, and prior electroconvulsive treatment linked to this higher dosing.
- * The findings indicate significant variations in MS usage among different countries and highlight specific patient characteristics that could help in the individualized treatment of BD.
Article Synopsis
- - The REAP BD study investigated psychotropic medication prescription patterns for bipolar disorder across 12 Asian countries, highlighting the prevalence of polypharmacy and varied treatment approaches.
- - Data collected from 2003 patients showed that a majority were on multiple medications: 80.8% took mood stabilizers, 82.14% took antipsychotics, and the study found that 70% of patients were involved in polypharmacy practices.
- - Results indicated a significant increase in antipsychotic use, with over 80% of patients receiving them, suggesting an emerging trend in their use for treating bipolar disorder.
Psychological Reactions of Hospital Workers to a Pandemic: A Comparison of SARS-CoV-2 in 2020 and SARS in 2003.
Int J Environ Res Public Health
January 2022
Epidemic viral infections, including the outbreak of severe acute respiratory syndrome (SARS) in 2003 and SARS-CoV-2 in 2019, have brought tremendous loss to people across the nations. The aim of this study was to compare the psychological impact of the SARS-CoV-2 pandemic in 2020 and the SARS pandemic in 2003 on hospital workers. Hospital workers at a medical center in Southern Taiwan ( = 1816) were invited to complete questionnaires (SARS-CoV-2 Exposure Experience, the Impact of Event Scale, the Chinese Health Questionnaire, and the Distress Thermometer).
View Article and Find Full Text PDFThe symptom heterogeneity of schizophrenia is consistent with Wittgenstein's analogy of a language game. From the perspective of precision medicine, this study aimed to estimate the symptom presentation and identify the psychonectome in Asian patients, using data obtained from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics. We constructed a network structure of the Brief Psychiatric Rating Scale (BPRS) items in 1438 Asian patients with schizophrenia.
View Article and Find Full Text PDFObjective: Recently, rational polypharmacy approaches have been proposed, regardless of the lower risk and cost of monotherapy. Considering monotherapy as first-line treatment and polypharmacy as rational treatment, a balanced attitude toward polypharmacy is recommended. However, the high prevalence of polypharmacy led the Japanese government to establish a polypharmacy reduction policy.
View Article and Find Full Text PDFStigma, depression, and anxiety among patients with head and neck cancer.
Support Care Cancer
February 2022
Purpose: Patients with head and neck cancer (HNC) are vulnerable to psychiatric comorbidities, particularly anxiety and depression, and also suffer from cancer stigma. This study aimed to comprehensively compare HNC patients' stigma, depression, and anxiety, and elucidate the underlying relationships among them.
Methods: This cross-sectional study recruited inpatients with HNC from a medical center.
Cognitive deficits, which are core manifestations in schizophrenia and exhibit a limited response to antipsychotic treatment, contribute to poor treatment outcomes and functional disability. Evidence on the effect of aerobic walking (AW) and exercise intensity on cognitive function in patients with schizophrenia is lacking. In total, 79 patients with schizophrenia were recruited for a 12-week randomized control trial and allocated to the treatment-as-usual (TAU, n = 38) and treatment-as-usual plus AW (TAW, n = 39) groups.
View Article and Find Full Text PDFArticle Synopsis
- The study examines the relationship between body mass index (BMI) and antipsychotic-induced extrapyramidal symptoms (EPS) in schizophrenia patients, noting an inverse correlation between BMI and EPS prevalence.
- Using data from 1,448 patients, the research found that underweight individuals were more likely to experience symptoms like muscle rigidity and bradykinesia.
- Overall, the findings suggest that lower BMI is linked to increased muscle rigidity among Asian schizophrenia patients, although the exact mechanisms are still unclear.
Article Synopsis
- The study investigates the coprescription of mood stabilizers (MSs) with antipsychotics in patients with schizophrenia across 14 Asian countries, finding that 13.6% of patients received MSs, often at high doses.
- Factors associated with MS use included demographic variables like younger age and female sex, as well as clinical aspects like longer illness duration and more severe symptoms.
- Results suggest that patients on high doses of MSs had a less favorable illness trajectory and were more challenging to treat, indicating that adjunctive MS treatment may reflect greater severity of illness.
Objective: Depression is a common comorbidity in cancer patients. This study aimed to compare the prevalence and associated factors of depressive disorder between patients with head and neck cancer (HNC) and those with lung cancer (LC).
Design: This study used a cross-sectional design with consecutive sampling.
Article Synopsis
- Network analysis, referred to as 'symptomics', identifies interconnected symptoms as part of a dynamic structure, applied to various symptom-related areas.
- The study used data from the REAP-AP project to create a network model of extrapyramidal syndrome in 1,046 Asian patients diagnosed with schizophrenia.
- Results indicated that dyskinesia was the most central symptom in the network, with three distinct clusters of extrapyramidal symptoms identified, suggesting a relationship between acute movement disorders and the risk of tardive dyskinesia.
Article Synopsis
- Patterns of clinical use of long-acting injectable (LAI) antipsychotics for treating schizophrenia in Asia are not well documented, with an average of 17.9% of patients receiving these medications across 15 countries.
- Patients on LAIs tend to be older, have a history of multiple hospitalizations, and experience more severe symptoms like disorganized behavior or aggression, but they also show slightly better psychosocial functioning.
- There are significant variations in the use of LAI antipsychotics among Asian countries, and clinicians need to consider both the benefits and potential adverse effects when prescribing these treatments.
Background: Substance abuse among young people has become a serious public health problem for years. The risk of relapse among illicit drug use is essential for developing adequate substance reuse prevention policies. The purpose of the current study is to investigate the potential predictor in long-term relapse rates among young patients that underwent a family-based treatment program.
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- The study aimed to analyze and compare the network structures of depressive symptoms among Asian patients using network analysis techniques.
- Researchers used data from 1174 patients and found that persistent sadness, fatigue, and loss of interest were the most central symptoms in the network of depressive disorders.
- The results indicated that geographic and economic factors may affect the expression and organization of depressive symptoms, suggesting cultural influences in how these symptoms manifest among different groups of Asian patients.
Purpose: Head and neck cancer (HNC) patients suffer from perceived shame and stigma due to the illness diagnosis, as well as disfigurement following surgery. To measure HNC patients' perception of shame and stigma, the Shame and Stigma Scale (SSS) was developed and preliminarily validated. In this study, we aimed to translate, adapt, and validate the SSS in Chinese.
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