The CoNi@C/MoC i-MXene Derived from Novel (MoR)GaC (R = Dy, Ho, Er, Tm, and Lu) Nanolaminations for Electrochemical Application in Electrocatalytic Hydrogen Evolution and Supercapacitance.

2D MoC i-MXene is highly promising for electrochemical applications. Here, a synthetic strategy is reported, enabling the uniform distribution of carbon-coated CoNi (CoNi@C) nanoparticles on the vacancy-ordered MoC i-MXene nanosheets, thereby fully exposing the active sites of CoNi@C. First, five novel Ga-containing (MoR)GaC (R = Dy, Ho, Er, Tm, and Lu) i-MAX phases are synthesized as the precursor and found to be crystallized into Cmcm structure, followed by hydrothermal etching and delamination.

Evolutionary Nonindependence Between Human piRNAs and Their Potential Target Sites in Protein-Coding Genes.

PIWI-interacting RNAs (piRNAs) are the most diverse small RNAs in animals. These small RNAs have been known to play an important role in the suppression of transposable elements (TEs). Protein-coding genes (PCGs) are the most well-recognized functional genes in genomes.

Main-Chain Azobenzene Poly(ether ester) Multiblock Copolymers for Strong and Tough Light-Driven Actuators.

The stimulus-responsive polymeric materials have attracted great research interest, especially those remotely manipulated materials with potential applications in actuators and soft robotics. Here we report a photoresponsive main-chain actuator based on azobenzene poly(ether ester) multiblock copolymer (mBCP) thermoplastic elastomers, (PTAD--PTMO--PTAD), which were synthesized by a cascade polycondensation-coupling ring-opening polymerization method using poly(tetramethylene oxide) (PTMO) and azobenzene-containing cyclic oligoesters (COTADs) as monomers. The thermal, mechanical, and microphase separation behaviors of mBCPs could be flexibly tuned by altering the ratios of soft-to-hard segments and block number ().

Efficient Solution Blow Spinning of PAN-CNTs Nanofiber-Based Pressure Sensors with Sandwich Structures.

High-performance sensors play a crucial role in smart wearable technology and human-machine interaction. However, traditional metal- and silicon-based sensors face drawbacks, including limited flexibility, high cost, degradation issues, and insufficient sensitivity. Conductive composite fibers were produced using the spinning solution of PAN and PVB mixed with CNTs and spun at a flow rate of 20 mL·h.

Multi-omic Analyses Shed Light on The Genetic Control of High-altitude Adaptation in Sheep.

Sheep were domesticated in the Fertile Crescent and then spread globally, where they have been encountering various environmental conditions. The Tibetan sheep has adapted to high altitudes on the Qinghai-Tibet Plateau over the past 3000 years. To explore genomic variants associated with high-altitude adaptation in Tibetan sheep, we analyzed Illumina short-reads of 994 whole genomes representing ∼ 60 sheep breeds/populations at varied altitudes, PacBio High fidelity (HiFi) reads of 13 breeds, and 96 transcriptomes from 12 sheep organs.

Highly sensitive and selective detection of amoxicillin using molecularly imprinted ratiometric fluorescent nanosensor based on quantum dots.

A dual-emission ratiometric fluorescence sensor (CDs@CdTe@MIP) with a self-calibration function was successfully constructed for AMO detection. In the CDs@CdTe@MIP system, non-imprinted polymer-coated CDs and molecule-imprinted polymer-coated CdTe quantum dots were used as the reference signal and response elements, respectively. The added AMO quenched the fluorescence of the CdTe quantum dots, whereas the fluorescence intensity of the CDs remained almost unchanged.

Rare-Earth (R) In-Plane Ordering in Novel (Mo, R, Nb)AlC Quinary o-MAX Nanolaminates and their 2D Derivatives.

Nanolamellar transition metal carbides are gaining increasing attentions because of the promising application in energy storage of their 2D derivatives. There are in-plane and out-of-plane atomic ordered occupations, which is thought to only be formed in separated systems due to totally different origins and crystallographic structure. In present work, starting from (Mo, Nb)AlC o-MAX phase where out-of-plane ordered occupation is experimentally and theoretically proved for Mo/Nb atoms, rare-earth elements (R = Y, Gd-Tm, Lu) are introduced, and the novel Mo RNbAlC (x = 1, 1.

HIF-2α inhibition disrupts leukemia stem cell metabolism and impairs vascular microenvironment to enhance chronic myeloid leukemia treatment.

Leukemic stem cells (LSCs) in chronic myeloid leukemia (CML) contribute to treatment resistance and disease recurrence. Metabolism regulates LSCs, but the mechanisms remain elusive. Here, we show that hypoxia-inducible factor 2α (HIF-2α) is highly expressed in LSCs in mouse and human CML and increases after tyrosine kinase inhibitor (TKI) treatment.

Association of plasma lactoferrin levels with disease severity in glaucoma patients.

Objective: To explore the relationship between plasma lactoferrin (Lf) and glaucoma, assessing the clinical utility of Lf in glaucoma.

Methods: A cross-sectional study involved 161 glaucoma patients and 115 healthy controls, with a follow-up of 14 subjects after approximately 2 years. Plasma Lf markers were quantified using ELISA, comparing levels between glaucoma patients and healthy controls, and analyzing plasma Lf across different glaucoma severity grades.

Compendium of 5810 genomes of sheep and goat gut microbiomes provides new insights into the glycan and mucin utilization.

Background: Ruminant gut microbiota are critical in ecological adaptation, evolution, and nutrition utilization because it regulates energy metabolism, promotes nutrient absorption, and improves immune function. To study the functional roles of key gut microbiota in sheep and goats, it is essential to construct reference microbial gene catalogs and high-quality microbial genomes database.

Results: A total of 320 fecal samples were collected from 21 different sheep and goat breeds, originating from 32 distinct farms.

IGF-1 Induces Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells by Promoting SOX4 via the MAPK/ERK Pathway.

Tissue engineering envisions functional substitute creation for damaged tissues. Insulin-like growth factor-1 (IGF-1) plays roles in bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation (OD), and we investigated its specific mechanism. BMSCs were cultured and OD was induced.

Fast Solution Blow Spinning of Lotus-Leaf-Inspired SiO Nanofiber Sponge for High Efficiency Purification.

Massive production of SiO nanofibers with both high durability and exceptional performance remains a significant challenge. Herein, a novel approach was introduced to achieve the massive production of SiO nanofibers with lotus-leaf-inspired surfaces by combining solution blowing spinning (SBS) and the polymer-derived ceramics method. Based on the SBS technique, three types of precursor nanofiber products were fast spined with methyl silsesquioxane polymer and polymethyl hydrogen siloxane employed as Si sources.

Unraveling the intrinsic mechanism behind the retention of arsenic in the co-gasification of coal and sewage sludge: Focus on the role of Ca and Fe compounds.

Minimizing the emission of arsenic (As) is one of the urgent problems during co-gasification of Shenmu coal (SM) and sewage sludge (SS). The intrinsic mechanism of As retention was obtained by analyzing the effect of different SM addition ratios on the As form transformation during co-gasification at 1000 °C under CO atmosphere. The results showed that the addition of SM effectively promoted the enrichment of As in the co-gasified residues.

Th1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner.

Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical significance, the underlying mechanisms of glaucoma pathogenesis remain poorly understood. In this study, we aimed to unravel the multifaceted nature of glaucoma by investigating the interaction between T cells and retinas.

Association between serum omentin-1 and mucosal disease activity in patients with ulcerative colitis.

Purpose: Mucosal inflammation is a key feature of ulcerative colitis (UC), a chronic relapsing and remitting form of inflammatory bowel disease. Omentin-1, a newly discovered adipokine, is reported to have anti-inflammatory effects and has been found to be decreased in patients with inflammatory bowel disease. The aim of our study was to investigate the association between serum omentin-1 levels and mucosal disease activity in patients with UC.

Octadecyl-fibrous mesoporous silica nanospheres coated 96-blade thin-film microextraction for high-throughput analysis of phthalic acid esters in food and migration from food packages.

A high-throughput sample pre-treatment method combined with high-performance liquid chromatography (HPLC) was developed to analyze phthalates (PAEs) in food and food contact package samples. Thin film microextraction (TFME) in 96-blade format was used to pre-treat 96 samples simultaneously. Octadecyl groups functionalized fibrous mesoporous silica nanospheres, namely C18-FMSNs, were synthesized and used as TFME coating material.

Pancancer analysis uncovers an immunological role and prognostic value of the m6A reader IGF2BP2 in pancreatic cancer.

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant gastrointestinal tumors worldwide with a dismal prognosis and high relapse rate. PDAC is considered a "cold cancer" for which immunotherapy is not effective. Therefore, to improve the prognosis for PDAC patients, it is urgent to explore the mechanism driving its insensitivity to immunotherapy.

In-Plane Chemical Ordering (MoR)AlB (R = Tb, Dy, Ho, Er, Tm, and Lu) i-MAB Phases and their Two-Dimensional Derivatives (MBene): Synthesis, Structure, Magnetic, and Supercapacitor Performance.

A family of hexagonal in-plane chemical ordering (MoR)AlB (R = Tb, Dy, Ho, Er, Tm, and Lu) i-MAB phases are synthesized with R-3m hexagonal structure. The i-MAB phases with R = Tb to Tm are considered to have a nonlinear ferromagnetic-like coupling magnetic ground state with gradually weakened magnetocrystalline anisotropy due to variant R-R distances and 4f electrons. Their 2D derivatives (2D-MBene) with rare-earth (R) atom vacancies are obtained by chemical etching.

Venetoclax Overcomes Sorafenib Resistance in Acute Myeloid Leukemia by Targeting BCL2.

Sorafenib, a kinase inhibitor, has shown promising therapeutic efficacy in a subset of patients with acute myeloid leukemia (AML). However, despite its clinical effectiveness, sorafenib resistance is frequently observed in clinical settings, and the mechanisms underlying this resistance as well as effective strategies to overcome it remain unclear. We examined both single-cell and bulk transcription data in sorafenib-resistant and control AML patients and integrated a sorafenib resistance gene signature to predict the sensitivity of AML cells and the clinical outcomes of AML patients undergoing sorafenib therapy.

Clinical significance of the C-reactive protein-to-bilirubin ratio in patients with ulcerative colitis.

Background: Ulcerative colitis (UC) is a chronic relapsing remitting disease of the colon. Appropriate monitoring of the disease status is necessary for patients to adopt optimal therapy and obtain a better prognosis. Finding an ideal non-invasive biomarker, which is suitable for long-term monitoring in clinical settings will bring a significant benefit to the individualized management of patients with UC.

Comprehensive assessment of the anterior segment in refraction corrected OCT based on multitask learning.

Anterior segment diseases are among the leading causes of irreversible blindness. However, a method capable of recognizing all important anterior segment structures for clinical diagnosis is lacking. By sharing the knowledge learned from each task, we proposed a fully automated multitask deep learning method that allows for simultaneous segmentation and quantification of all major anterior segment structures, including the iris, lens, cornea, as well as implantable collamer lens (ICL) and intraocular lens (IOL), and meanwhile for landmark detection of scleral spur and iris root in anterior segment OCT (AS-OCT) images.