Publications by authors named "Chon-Chon Zhao"
Article Synopsis
- The link between diabetes and Alzheimer's disease (AD) involves hyperphosphorylation of tau protein, which is influenced by CDK5 levels that may increase due to diabetes-related hyperglycemia.
- In a study with rats, those induced with diabetes showed worse behavior and changes in the CDK5 promoter, suggesting that diabetes negatively impacts cognitive function.
- Inhibiting a specific acetyltransferase reduced CDK5 activation and tau phosphorylation, leading to improved behavior in rats, indicating that diabetes may contribute to AD development through histone modifications.
Cyclin-dependent kinase-5 (CDK5) is activated by p35 and then binds to both p35 and its truncated form p25 to promote hyperphosphorylation of tau protein, thereby facilitating the pathological progression of Alzheimer's disease (AD). However, it is unknown whether a patient's diabetic status promotes the later onset of AD in a CDK5-dependent manner. Here, we induced pro-diabetic insulin resistance and glucose intolerance in rats using a combined high fat and high glucose diet.
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