[Odontogenic induction and ameloblastoma. Histoenzymological and ultrastructural studies (author's transl)].

The ameloblastoma is usually thought to be devoid of any odontogenic capacity. However, the histological, ultrastructural and histoenzymological study of 5 cases demonstrates the fairly high level of differentiation of some ameloblastic cells in such neoplasms. Furthermore, it suggests very early stage of epithelio-conjunctive interaction.

[Tendinous hyperlipoproteinaemic xanthomatosis associated with supravalvular aortic xanthomatosis (author's transl)].

A 56-year-old woman with familial heterozygous type II hyperlipoproteinaemia and tendinous xanthomas, presented the unusual findings of acquired supravalvular aortic stenosis associated with a congenital stenosis of the orifice. Analysis of clinical, paraclinical, and particularly pathological data confirmed the existence of several associated lesions: congenital hypoplasia of the aortic ring and proximal aorta, calcified valve stenosis probably increased by the dyslipidaemia, and finally and principally, supravalvular stenosis formed of a veritable circular rim of atheromatous material, making up a second haemodynamic obstacle. It is probable that the pre-existing congenital aortic lesions in this case, apart from the hyperlipoproteinaemia, account for the observation, not previously reported in a heterozygous type II hyperlipoproteinaemia, of massive supravalvular atheromatous deposits.

[Desmoid fibroma of bone. An histoenzymological and ultrastructural study of the mandible in one case (author's transl)].

A case of post-traumatic desmoid tumor of the mandible is reported in a 4-year old girl. This tumor was considered typical clinically and by light microscopy. Four years later, the patient was symptomless, without evidence of recurrence.

Effects of irradiation on the submandibular gland of the rat. An enzyme histochemical and ultrastructural study.

Single-dose cervical irradiation by cobalt 60 in rats induced lasting functional disturbances of the submandibular gland which were excessive when compared with the relative integrity of the gland as seen under the light microscope. Enzyme histochemical and ultrastructural studies revealed severe damage shortly after exposure with appearance of karyolytic bodies and autophagosomes accompanied by increased hydrolase activity. Mitochondrial alterations were concomitant with diminished ductal oxidative enzyme activity.

[Cardiac manifestations of the hypereosinophilia syndrome: a report on fifteen cases (author's transl)].

A retrospective study was conducted in fifteen patients with the hypereosinophilia syndrome to assess the cardiac manifestations of the affection. Clinical, electrical, and radiological findings, together with the results of ultrasonography (8 cases), hemodynamic tests (6 cases), and pathological examinations (7 cases) were used to classify the fifteen patients into four groups: 7 cases with endomyocardial fibrosis (EMF), 5 with non-obstructive cardiomyopathy (NOCM), 2 with pre-existing cardiopathies, and 1 with a normal heart. The manifestations in the 7 EMF cases varied according to the extent of the fibrosis present: 2 adiastolies, 3 valve incompetences, and 2 asymptomatic forms.

[Angio-immunoblastic lymphadenopathy and neurological manifestations (author's transl)].

Cases of associated angio-immunoblastic lymphadenopathy (AIL) and peripheral neuropathies have been rarely reported in the literature. Three such cases are described, in two men and one woman aged 79, 59, and 45 years respectively. Diagnosis of AIL was confirmed by lymph node biopsy in the two latter patients during their lifetime, and in the first case from examination of cervical nodes at autopsy.

[Relapsing polychondritis. Histochemical, histoenzymological, immunofluorescent and ultrastructural studies of ear cartilage in three cases (author's transl)].

Ear cartilage has been studied by histochemistry, histoenzymology, immunofluorescence and electron microscopy in three cases of relapsing polychondritis. The most significant lesions have been observed at the cellular level, both by enzymology and electron microscopy: chondrocytes of peripheral zones seem to be first hypertrophic and then necrotic; at the opposite, their is no correlation between histochemical and electron microscopic studies about the chondroid intercellular substance whom lesions are probably secondary to the cellular ones. A few chondrocytes are positive with antiimmunoglobulins sera (IgM and IgA); this fact could be a proof of the dysimmune nature of this disease.

[Thyroid metastases from renal tumours: 3 cases (author's transl)].

Metastatic tumours from clear cell renal cancer were found in 3 out of 4 000 thyroidectomy specimens. These tumours appeared on scintigrams as low density nodules, one to three in number, and were accompanied in one case by signs of hyperthyroidism. They were treated by partial excision 4, 5 and 7 years after nephrectomy.

[Muscular metastasis, first symptom of bronchial carcinoma (author's transl)].

One case of bronchial carcinoma in which a muscular metastasis was the presenting symptom is reported. Clinical features included pain and gradual swelling of left musculus supra-spinatus. Surgical biopsy showed intra-muscular metastasis of bronchial origin.

[White sponge nevus-type familial leucodysplasia of the oral cavity. Electron microscopic study of a case].

In a case of white sponge naevus type congenital buccal keratosis, electron microscopic study revealed severe disturbances in filamentogenesis which was insufficient (pale cells) or on the contrary excessive and anarchic (dark cells) and, to a lesser degree, corneal maturation. This was accompanied by slight abnormalities of the cellular junctions, rarely described in such a condition up to the present time. With regard to the delayed epithelial exfoliation typical of this condition, the manner and causes of its development are discussed in the light of ultrastructural findings.

[Histogenesis of giant cell tumors of bone. comparative, ultrastructural and histo-enzymologic study of osteoforming tumors and malignant and giant cell tumors].

Comparative ultrastructural and histoenzymological study of 10 osteogenic (4 osteosarcomas), osteolytic (3 benign giant cell tumours, 2 malignant osteoclastomas) and fibrosarcomatous osseous tumours of the jaw emphasised the analogies between osteoblasts and fibroblastic stromal cells of giant cell tumours. These two cell types, with their abundant granular ergastoplasm, secrete a collagen interstitial fibrillary substance which is capable of secondary calcification. Their enzyme activities, with regard to oxidative mechanisms and protein synthesis are identical.

[Osteogenesis imperfecta and aortic incompetence. One case with pathological findings. Review of the literature (author's transl)].

Cardiovascular manifestations of Lobstein's disease are rare, probably unrecognized, and determining factors for the final prognosis, the most frequent lesion being aortic incompetence. The eleventh case to be reported with pathological findings in the literature is described. This complication is usually found in men, blood regurgitation being large in amount, symptomatic, and progressive.

[Non-bacterial thrombotic endocarditis. Autopsy study, clinico-pathological correlations (author's transl)].

During the course of 6 000 autopsies, the number of cases of non-bacterial thrombotic endocarditis discovered was 130 (absolute frequency of 2.1 p. cent).

[Diabetic glomerulosclerosis in the DBM mouse. Correlated study of quantitative morphology, immunofluorescence and electronic microscopy].

Using an experimental model of genetic diabetes (DBM mouse) a comparison was made of the results of quantitative data obtained by light and electron microscopy (measurement of glomerular and mesangial surface areas, assessment of the thickness of the basal membrane and its irregularities) and was used to demonstrate the actual presence of glomerulosclerosis in the renal parenchyma of 31 diabetic animals. In addition, immunofluorescent investigations in these same animals demonstrated the presence of serum proteins (in particular immunoglobulins and albumin) in the glomerulus and the tubular basal membrane. These substances transude through the vessels as a result of increased vascular permeability.

[Histogenesis of lobular cancer of the breast. Histoenzymatic and ultrastructural study of a muciparous cell invasive epithelioma].

A comparative light microscopy, histoenzymological and ultrastructural study enabled the authors, in a case of invasive lobular carcinoma of the breast, to emphasise certain special morphological traits of this tumour type and to make a contribution to the understanding of its histogenesis. By light microscopy, the only special features of the case were the abundance of mucus secreting tumour cells in the perilobular infiltrating zones and in the stromal texture with marked perigalactophoric hyalinosis and active elastic neogenesis. From an ultrastructural standpoint, intralobular malignant zones contained epithelial type cells, rich in microfilaments and with numerous desmosomal junctions.

[Metastatic pulmonary emboli: clinical types and incidence (author's transl)].

Pathological examinations during autopsy of 1457 cases of cancer demonstrated the presence of metastatic pulmonary emboli in 10 p. cent (148 cases). The were divided, as a function of their site and histological type of the primary neoplasm, as follows: hepatoma 33 p.

[Cytoenzymological, immunological and scanning electron microscopic studies on 49 cases (author's transl)].

Light cytology, enzymology, immunofluorescence and scanning electron microscopy have been performed on 49 bronchoalveolar fluids recovered by bronchoscopic lavage. The patients had the following lung diseases: infectious pneumonitis (19 cases), pulmonary fibrosis (13 cases) including 5 sarcoïdosis, 3 idiopathic pulmonary fibrosis and 5 silicosis, hypersensitivity pneumonitis (5 cases) and miscellaneous lung tumors (12 cases). Cytologic studies in comparison with clinical aspects show 4 groups: Group I (chronic bronchopneumopathy and inactive fibrosis) presents numerous cells but few lymphocytes (less than 5%); in Group II (evolutive fibrosis) have an increase percentage of lymphocytes (20%); in Group III (hypersensitivity pneumonitis) is observed a very high percentage of lymphocytes (45%); and in Group IV (cancerous lung diseases) values are not far from normal percentage except for lymphomas.