Use of plasmid profiles in the investigation of a patient with Helicobacter pylori infection and peptic ulcer disease.

Plasmids may effect bacterial virulence and antibiotic resistance, and serve as epidemiologic markers. In this study, plasmid DNA profiles of serial isolates of Helicobacter pylori showed persistence of an identical strain of this organism in a patient with duodenal ulcer disease. Three control strains of H.

Streptococcus bovis brain abscess associated with an occult colonic villous adenoma.

Streptococcus bovis is now recognized as a common cause of bacterial endocarditis. However, infection of the central nervous system by this organism is very rare. Recent studies have demonstrated the association between Streptococcus bovis infections and colonic neoplasms.

Campylobacter pylori and gastroduodenal disease: a prospective endoscopic study and comparison of diagnostic tests.

A series of 72 adult patients undergoing 76 upper gastrointestinal (GI) endoscopies because of GI signs or symptoms were studied for the presence of Campylobacter pylori by culture, histology, and rapid urease determination of gastric antral biopsy specimens. C. pylori was found by culture or histology in all 10 cases of gastric and duodenal ulcer, and in 77% of endoscopies with histologically proven active gastritis.

Campylobacter pylori antibodies in humans.

Study Objective: To determine the diagnostic value of assays to measure serum antibodies to Campylobacter pylori, and to use these assays to determine the prevalence of C. pylori infection in a healthy population.

Design: A survey of patients having endoscopies for upper gastrointestinal symptoms, patients with other gastrointestinal illnesses, and healthy controls.

Pharmacokinetics of intravenous cefotaxime in patients undergoing chronic hemodialysis.

The pharmacokinetics of intravenously administered cefotaxime were studied in 11 patients with creatinine clearances of less than 7 ml/min who were undergoing chronic hemodialysis. Eight were studied during dialysis, and 3 were studied between dialyses. Pharmacokinetic parameters were determined using a two-compartment linear model.

An epidemiologic study of 100 cases of toxoplasmic uveitis: implications for diagnosis and prevention.

An epidemiologic study of 100 patients with active chorioretinitis, positive Sabin-Feldman methylene-blue dye-test, and favourable response to antitoxoplasmic drugs (spiramycin) was undertaken to establish a basis for rapid clinical diagnosis and institution of preventive measures for toxoplasmic uveitis. Eighty-two of the 100 patients, but only 19 of 100 controls, gave positive histories of exposure to likely sources of toxoplasmosis, such as hunting and handling of wild game, ingestion of raw meat, etc. Seventy-six of these 82 patients had positive toxoplasmin skin tests, but all subsequently had positive dye-tests.