Publications by authors named "Cho-Lu Li"
Article Synopsis
- NSC746364, NSC746365, and NSC746366 are new anticancer compounds that were tested for their effectiveness against 60 human cancer cell lines, revealing a distinctive pattern of activity compared to existing treatments.
- The study measured cytotoxicity using the MTT assay and assessed telomerase activity through specialized PCR methods, finding that these compounds can significantly inhibit cell growth at specific doses.
- Results showed that each compound has substantial growth inhibition and lethality effects, with the lowest effective doses recorded, emphasizing their potential use as anticancer agents through telomerase inhibition.
Telomerase is important in tumor initiation and cellular immortalization. Given the striking correlations between telomerase activity and proliferation capacity in tumor cells, telomerase had been considered as a potentially important molecular target in cancer therapeutics. A series of 2,7-diamidoanthraquinone were designed and synthesized.
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