c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD cleavage activity to inhibit mitochondrial respiration.

Mitochondrial dysfunction is a key pathological feature of many different types of neurodegenerative disease. Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) has been attracting much attention as an important molecule for inducing axonal degeneration and neuronal cell death by causing loss of NAD (NADH). However, it has remained unclear what exactly regulates the SARM1 activity.

The behavior of hair from different countries.

The properties of curly hair from different countries were assessed using geometrical measurements from a laser scanning micrometer and a new hair shape classification method. In addition, tensile tests, 2-D gel electrophoresis, and differential scanning calorimetry (DSC) were performed. Results concluded that hair characteristics are influenced by the degree of curl.