Publications by authors named "Chloe de Witte"

Background: Gastric non-Helicobacter pylori helicobacters (NHPH) naturally colonize the stomach of animals. In humans, infection with these bacteria is associated with chronic active gastritis, peptic ulceration and MALT-lymphoma. H.

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Background: Gastric non-Helicobacter pylori Helicobacter (NHPH) species naturally associated with animals have been linked with gastric disease in human patients.

Aim: The prevalence and clinical significance of zoonotic gastric NHPHs was determined in large and well-defined, H. pylori-negative, gastric patient populations.

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The gut microbiota represents a diverse and dynamic population of microorganisms that can influence the health of the host. Increasing evidence supports the role of the gut microbiota as a key player in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease (AD). Unfortunately, the mechanisms behind the interplay between gut pathogens and AD are still elusive.

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The genus is composed of bacteria that colonize both the human and animal gastrointestinal tract. infects half of the world's population, causing various disorders, such as gastritis, duodenitis and gastric cancer. Additionally, non- species (NHPH) are commonly found in the stomach of pigs, dogs and cats.

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() is a Gram-negative bacterium that infects half of the human population worldwide, causing gastric disorders, such as chronic gastritis, gastric or duodenal ulcers, and gastric malignancies. is mainly associated with pigs, but can also colonize the stomach of humans, resulting in gastric pathologies. In pigs, can induce gastritis and seems to play a role in gastric ulcer disease, seriously affecting animal production and welfare.

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Broad-spectrum beta-lactamase (BSBL)-producing impose public health threats. With increased popularity of zoos, exotic animals are brought in close proximity of humans, making them important BSBL reservoirs. However, not much is known on the presence of BSBLs in zoos in Western Europe.

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Gastric helicobacters ( () and non- species (NHPHs)) colonize the stomach of humans and/or animals. species identification is essential since many of them are recognized as human and/or animal pathogens. Currently, species can only be differentiated using molecular methods.

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This study reports the comparative analyses of four Flavobacterium columnare isolates that have different virulence and antimicrobial resistance patterns. The main research goal was to reveal new insights into possible virulence genes by comparing the genomes of bacterial isolates that could induce tissue damage and mortality versus the genome of a non-virulent isolate. The results indicated that only the genomes of the virulent isolates possessed unique genes encoding amongst others a methyl-accepting chemotaxis protein possibly involved in the initial colonization of tissue, and several VgrG proteins engaged in interbacterial competition.

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Article Synopsis
  • A study used a combination of agar and broth dilution methods along with qPCR to evaluate the antimicrobial susceptibility of feline isolates, revealing different distributions of Minimum Inhibitory Concentrations (MICs) for various antibiotics.
  • The research identified specific single nucleotide polymorphisms (SNPs) in ribosomal proteins linked to resistance against azithromycin and spectinomycin, while the resistance mechanisms for enrofloxacin and lincomycin remain unclear.
  • Feline isolates exhibited higher MICs for neomycin, potentially due to SNPs in ribosomal protein genes, highlighting the risk of antimicrobial resistance in pets and the potential implications for human health.
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The porcine Helicobacter suis and canine-feline H. heilmannii are gastric Helicobacter species with zoonotic potential. However, little is known about the pathogenesis of human infections with these Helicobacter species.

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Helicobacter suis has been associated with development of gastric ulcers in the non-glandular part of the porcine stomach, possibly by affecting gastric acid secretion and altering the gastric microbiota. Fusobacterium gastrosuis is highly abundant in the gastric microbiota of H. suis-infected pigs and it was hypothesized that this micro-organism could play a role in the development of gastric ulceration.

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Background: Infections with gastric Helicobacter spp. are associated with gastritis, peptic ulceration, and malignancies. Helicobacter pylori is the most prevalent Helicobacter species colonizing the human stomach.

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The minimum inhibitory concentration of bambermycin on three porcine Helicobacter suis strains was shown to be 8 μg/mL. The effect of in-feed medication with this antibiotic on the course of a gastric infection with one of these strains, the host response and the gastric microbiota was determined in mice, as all of these parameters may be involved in gastric pathology. In H.

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Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys.

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This article aimed to review the literature from 2015 dealing with gastric and enterohepatic non-Helicobacter pylori Helicobacter species (NHPH). A summary of the gastric microbiota interactions with H. pylori is also presented.

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