Patient views on continued immune checkpoint inhibition following progression in advanced melanoma: A qualitative study.

Introduction: Immune checkpoint inhibition has revolutionized the management of metastatic melanoma, including in the final stages of disease progression: because it is well tolerated, some teams do not discontinue it in hopes of slowing disease progression. The risks are that treatment may be continued unnecessarily, causing side effects, and reduce access to specialist palliative care, in addition to increasing the cost of treatment.

Method: We explored the experiences of 10 patients in a university hospital with metastatic melanoma under continued immune checkpoint inhibitors combined with specialist palliative care.

Dexmedetomidine and clonidine in palliative medicine: multicentric qualitative evaluation.

Objectives: Alpha-2 agonists have analgesic and sedative properties that can prove interesting in palliative care. The main objective of this study was to describe the use of clonidine and dexmedetomidine in palliative care units (PCU). The secondary objective was to identify physicians' perspectives and attitudes toward alpha-2-agonists.

Current state and next-generation CAR-T cells in multiple myeloma.

Chimeric antigen receptor T cells (CAR-T cells) have emerged as a potentially transformative new approach to treating hematological malignancies. Ide-cel, an autologous B cell maturation antigen (BCMA) targeting CAR-T cells, has recently been approved to treat multiple myeloma (MM). Here, we review the main clinical trials of CAR-T cells in MM with the most advanced autologous BCMA-directed ide-cel and cilta-cel, the human CARs orva-cel and CT053, the alternative manufacturing process with P-BCMA-101 and bb21217, the dual CAR GC012F and the allogenic BCMA-directed CAR-T cells ALLO-715.

End-of-life Comfort Evaluation, is Clinic Enough? A Retrospective Cohort Study of Combined Comfort Evaluation with and Clinic in non-Communicative Patients.

Comfort evaluation is one of the major challenges in the palliative care setting, particularly when it comes to non-communicative patients. For this specific population, validated tools for comfort evaluation are scarce and healthcare professionals have to rely on their clinical sense and experience. To provide arguments for the use of Analgesia/Nociception Index (ANI) monitoring in order to improve clinical comfort evaluation.

[Palliative care in hematopoietic stem-cell transplanted patients: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Allogeneic hematopoietic cell transplantation (allo-HCT), the only curative therapy for numerous hematological malignancies, carries a significant risk of morbidity and mortality. The patients and families' expectations regarding the procedure, the prognosis uncertainties, as well as the existence of potential new therapeutic possibilities, lead to frequent use of intensive care. Even though the transplant physicians are highly skilled in acute care, their knowledge of palliative approach is limited, making the use of palliative care insufficient and often late.

Impact of equatorial Atlantic variability on ENSO predictive skill.

El Niño-Southern Oscillation (ENSO) is a key mode of climate variability with worldwide climate impacts. Recent studies have highlighted the impact of other tropical oceans on its variability. In particular, observations have demonstrated that summer Atlantic Niños (Niñas) favor the development of Pacific Niñas (Niños) the following winter, but it is unclear how well climate models capture this teleconnection and its role in defining the seasonal predictive skill of ENSO.

Home hospitalization for palliative cancer care: factors associated with unplanned hospital admissions and death in hospital.

Background: Home hospitalization at the end of life can sometimes be perturbed by unplanned hospital admissions (UHAs, defined as any admission that is not part of a preplanned care procedure), which increase the likelihood of death in hospital. The objectives were to describe the occurrence and causes of UHAs in cancer patients receiving end-of-life care at home, and to identify factors associated with UHAs and death in hospital.

Methods: A retrospective, single-center study (performed at a regional cancer center in the city of Lille, northern France) of advanced cancer patients discharged to home hospitalization between January 2014 and December 2017.

[Palliative care medical consultation in a hematology department. Feedback and critical reflection on a year of practice].

Introduction: Patients with hematological malignancies have less access to palliative care than other cancer patients, and benefit from it later in the course of their disease, though symptom burden is just as heavy.

Methods: We created a specialized outpatient palliative care consultation in the hematology department to improve the quality of patient management and enhance cooperation with hematologists.

Results: We found that though patient characteristics and survival were extremely variable, they all had in common a need for symptom management and care coordination.

Midazolam sedation in palliative medicine: retrospective study in a French center for cancer control.

Background: French legislation about sedation in palliative medicine evolved in 2016 with the introduction of a right to deep and continuous sedation, maintained until death. The objective was to describe midazolam sedation at the COL (Centre Oscar Lambret [Oscar Lambret Center], French regional center for cancer control), in order to establish a current overview before the final legislative changes.

Methods: Descriptive, retrospective and single-center study, concerning major patients in palliative care hospitalized from 01/01/2014 to 12/31/2015, who had been sedated by midazolam.

Sensitivity of winter North Atlantic-European climate to resolved atmosphere and ocean dynamics.

Northern Hemisphere western boundary currents, like the Gulf Stream, are key regions for cyclogenesis affecting large-scale atmospheric circulation. Recent observations and model simulations with high-temporal and -spatial resolution have provided evidence that the associated ocean fronts locally affect troposphere dynamics. A coherent view of how this affects the mean climate and its variability is, however, lacking.

Barriers to end-of-life discussions among hematologists: A qualitative study.

Background: Integrated palliative care is correlated with earlier end-of-life discussion and improved quality of life. Patients with haematological malignancies are far less likely to receive care from specialist palliative or hospice services compared to other cancers.

Aim: The main goal of this study was to determine hematologists' barriers to end-of-life discussions when potentially fatal hematological malignancies recur.

Land-surface initialisation improves seasonal climate prediction skill for maize yield forecast.

Seasonal crop yield forecasting represents an important source of information to maintain market stability, minimise socio-economic impacts of crop losses and guarantee humanitarian food assistance, while it fosters the use of climate information favouring adaptation strategies. As climate variability and extremes have significant influence on agricultural production, the early prediction of severe weather events and unfavourable conditions can contribute to the mitigation of adverse effects. Seasonal climate forecasts provide additional value for agricultural applications in several regions of the world.