Correction: UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells.

[This corrects the article DOI: 10.18632/oncotarget.15182.

UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells.

Esophageal cancer remains a poor prognosis cancer due to advanced stage of presentation and drug resistant disease. To understand the molecular mechanisms influencing response to chemotherapy, we examined genes that are differentially expressed between drug sensitive, apoptosis competent esophageal cancer cells (OE21, OE33, FLO-1) and those which are more resistant and do not exhibit apoptosis (KYSE450 and OE19). Members of the ISG15 (ubiquitin-like) protein modification pathway, including UBE2L6 and ISG15, were found to be more highly expressed in the drug sensitive cell lines.