Publications by authors named "Chloe Higgins"

Article Synopsis
  • This study investigates the effect of melatonin on reducing cesarean births during labor induction, hypothesizing that it may help lower the need for surgical intervention.
  • The trial was randomized and double-blind, involving 189 women with healthy singleton pregnancies, comparing those given 10 mg of melatonin to a placebo.
  • Results showed that cesarean rates were similar between the two groups, but the melatonin group had a lower rate of spontaneous vaginal births within 24 hours, leading to early termination of the trial due to logistical issues from the COVID-19 pandemic.
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This study describes the extent, quality and cultural appropriateness of current research on the health conditions of refugee children aged 0-6 years settled in high-income countries. A systematic review was conducted, including original articles published on the health conditions experienced by refugee children. A total of 71 papers were included.

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Microplastics determined in surface water trawls from coastal waters around Plymouth, southwest England, ranged from 0.26 to 0.68 n m, with a decrease evident from the lower estuaries of the Tamar and Plym to areas in Plymouth Sound more remote from urbanisation.

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Objective: This study aimed to compare the prognostic accuracy of intrapartum transperineal ultrasound measures of fetal descent before operative vaginal birth in predicting complicated or failed procedures.

Data Sources: We performed a predefined systematic search in Medline, Embase, CINAHL, and Scopus from inception to June 10, 2022.

Study Eligibility Criteria: We included studies assessing the following intrapartum transperineal ultrasound measures before operative vaginal birth to predict procedure outcome: angle of progression, head direction, head-perineum distance, head-symphysis distance, midline angle, and/or progression distance.

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Purpose: Hysterectomy is a common but expensive and morbid procedure. Alternative treatments for heavy menstrual bleeding (HMB) are effective in up to 80% of cases, but there is substantial variation in surgical approach and pre-operative management of HMB. This study aims to assess the approach to hysterectomies for benign indications including alternative treatments and route of operation.

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Study Question: Does the presence of adenomyosis in women treated with IVF alter IVF outcomes?

Summary Answer: Adenomyosis does not significantly alter IVF outcomes when adjusted for confounding factors including maternal age and smoking status.

What Is Known Already: Studies evaluating adenomyosis and its impact on infertility, particularly when focusing on IVF, remain controversial. Many studies report that adenomyosis has a detrimental effect on IVF outcomes, however age is strongly related with both the prevalence of adenomyosis and worse reproductive outcomes.

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Background & Aims: Helicobacter pylori induces strong inflammatory responses that are directed at clearing the infection, but if not controlled, these responses can be harmful to the host. We investigated the immune-regulatory effects of the innate immune molecule, nucleotide-binding oligomerization domain-like receptors (NLR) family CARD domain-containing 5 (NLRC5), in patients and mice with Helicobacter infection.

Methods: We obtained gastric biopsies from 30 patients in Australia.

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Background: There is currently limited evidence available regarding ideal timing for frozen embryo transfer (FET). Demonstrating that delaying FETs has few clinical benefits would allow patients to proceed with FET at their earliest convenience.

Aims: To examine whether the time interval between stimulation cycle and subsequent FET affects pregnancy and live birth rates.

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