Two-Year Patient-Reported Outcomes are Predictive of Mid- and Long-Term Outcomes Following Meniscal Allograft Transplantation.

Purpose: To determine if short-term patient reported outcomes (PROs) following meniscal allograft transplantation (MAT) correlate with mid- to long-term PROs at a minimum of 5-year follow-up.

Methods: A retrospective review was performed of MATs performed between 2001 and 2019 that had preoperative, 2-year, and minimum 5-year postoperative PROs. Patient-reported outcomes of interest assessed included International Knee Documentation Committee (IKDC) Score, all subscales of the Knee Injury and Osteoarthritis Outcome Score (KOOS), and Lysholm score.

Experts Achieve Consensus on a Majority of Statements Regarding Ethics, Transparency, Regulation and Best Practices for the Use of Orthobiologics.

Purpose: To establish consensus statements via a modified Delphi process about ethics, transparency, regulation and best practices for the use of orthobiologics in clinical practice for musculoskeletal pathology.

Methods: A consensus process on the regulation of orthobiologics at the provider-level was conducted using a modified Delphi technique. Twenty orthopaedic surgeons, sports medicine physicians, or basic scientists participated.

Adolescent seizure impacts oligodendrocyte maturation, neuronal-glial circuit Formation, and myelination in the mammalian forebrain.

Oligodendrocyte progenitor cells differentiate into oligodendrocytes, which myelinate axons during development and following demyelinating injury. However, the mechanisms that drive the timing and specificity of developmental myelination are not well understood. We hypothesized that oligodendrocyte progenitor cell proliferation and differentiation would be affected by pathological neuronal activity during adolescent development when developmental myelination is occurring and that this would also impact neuron-to-oligodendrocyte progenitor cell connectivity and myelination.