Publications by authors named "Chloe E C Williams"
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis reported across the world and is characterized by immunoglobulin A (IgA) dominant mesangial deposits, which are poorly -glycosylated. This deposition leads to a cascade of glomerular and tubulointerstitial inflammation and fibrosis, which can progress to chronic kidney disease. The variability in rate of progression reflects the many genetic and environmental factors that drive IgAN.
View Article and Find Full Text PDFObjective: This study aimed to assess the number of prescriptions that were uncollected by caregivers to identify any predisposing systemic themes that may act as barriers to children receiving medications.
Study Design And Setting: Data were retrospectively collected on uncollected prescriptions at a single, tertiary paediatric centre over a 2-month period. This included type and classification of the drug, prescriber specialty, the timing of prescription and the child's registered postcode.
Article Synopsis
- Immunoglobulin A (IgA) vasculitis (IgAV), also known as Henoch-Schoenlein purpura, is the most common childhood vasculitis that usually resolves on its own, but can lead to significant kidney issues (IgAV-N) in some patients.
- Current treatments focus on established kidney involvement, but there's a push for early intervention to prevent inflammation before serious kidney damage occurs.
- Research is ongoing to identify new therapeutic targets and drugs aimed at preventing kidney problems in children with IgAV-N, as current options like corticosteroids have proven ineffective for this purpose.
Background: Nephritis is a recognised complication of IgA vasculitis (IgAV, Henoch-Schönlein purpura) contributing to 1-2% of all chronic kidney disease (CKD) stage 5. Improved understanding may reduce irreversible damage in IgAV nephritis (IgAV-N).
Objective: The aim of this study was to perform a comprehensive systematic literature review to identify promising clinical and pre-clinical urine biomarkers in children with IgAV-N that could predict the presence of nephritis and/or determine its severity.