Publications by authors named "Chloe D Devillard"
Vascular Tissue Engineering: Challenges and Requirements for an Ideal Large Scale Blood Vessel.
Front Bioeng Biotechnol
October 2021
Since the emergence of regenerative medicine and tissue engineering more than half a century ago, one obstacle has persisted: the creation of large-scale vascular tissue (>1 cm) to meet the clinical needs of viable tissue grafts but also for biological research applications. Considerable advancements in biofabrication have been made since Weinberg and Bell, in 1986, created the first blood vessel from collagen, endothelial cells, smooth muscle cells and fibroblasts. The synergistic combination of advances in fabrication methods, availability of cell source, biomaterials formulation and vascular tissue development, promises new strategies for the creation of autologous blood vessels, recapitulating biological functions, structural functions, but also the mechanical functions of a native blood vessel.
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- 4D printing is a cutting-edge method that could produce advanced smart materials, featuring complex functionalities in the near future.
- Researchers have introduced a technique to create 4D printed objects that encapsulate two enzymes – alkaline phosphatase and thrombin – during the printing process, enabling them to exhibit beneficial biological activities.
- The entrapped enzymes allow for controlled calcification and the generation of a fibrin biofilm with living cells on the surface of 3D prints, which is assessed using various analysis methods like microscopy and MRI.