Publications by authors named "Chloe Cerutti"
From the comparative study of a circRNA originating from an mammalian ATXN2L intron to understanding the genesis of intron lariat-derived circRNAs.
Biochim Biophys Acta Gene Regul Mech
May 2022
Circular intronic RNAs (ciRNAs) are still unexplored regarding mechanisms for their emergence. We considered the ATXN2L intron lariat-derived circular RNA (ciRNA-ATXN2L) as an opportunity to conduct a cross-species examination of ciRNA genesis. To this end, we investigated 207 datasets from 4 tissues and from 13 mammalian species.
View Article and Find Full Text PDFArticle Synopsis
- Circular RNAs are prevalent across various species and tissues, with this study focusing on their transcription in farm animals like pigs, sheep, and cattle using 66 RNA-seq datasets.
- The analysis finds that ruminant liver tissues contain more exonic circRNAs than muscle tissues, and the number of exonic circRNAs in testis correlates with the animal's sexual maturity.
- The study also reveals that sub-exonic circRNAs arise from both multi-exonic and mono-exonic genes, suggesting a relationship between circRNA and linear gene transcription levels, highlighting the need for better genome annotation to fully understand circular transcriptomes.