Dopamine internalization via Uptake and stimulation of intracellular D-receptor-dependent calcium mobilization and CDP-diacylglycerol signaling.

Dopamine stimulates CDP-diacylglycerol biosynthesis through D-like receptors, particularly the D subtype most of which is intracellularly localized. CDP-diacylglycerol regulates phosphatidylinositol-4,5-bisphosphate-dependent signaling cascades by serving as obligatory substrate for phosphatidylinositol biosynthesis. Here, we used acute and organotypic brain tissues and cultured cells to explore the mechanism by which extracellular dopamine acts to modulate intracellular CDP-diacylglycerol.