Publications by authors named "Chizumi Nakamoto"
One possible mechanism underlying inflammation-induced sensitization of the primary afferent neuron is the upregulation of tetrodotoxin-resistant (TTX-R) Na(+) current by inflammatory mediators such as prostaglandins. This notion is based on reports that showed an augmentation of TTX-R Na(+) current following an application of prostaglandin E(2) (PGE(2)) in dorsal root ganglion (DRG) neurons. However, no information was available on the properties of the novel type of TTX-R Na(+) channel, Na(V)1.
View Article and Find Full Text PDFArticle Synopsis
- Small neurons in the dorsal root ganglion (DRG) express various voltage-gated Na(+) channel subtypes, with two being resistant to tetrodotoxin (TTX), affecting action potential generation.
- Research using wild-type and Na(V)1.8 knock-out mice showed that action potentials in small DRG neurons primarily rely on TTX-R/slow Na(+) current, while TTX-S/fast Na(+) current functions differently under varying conditions.
- TTX-R/persistent Na(+) current, mediated by Na(V)1.9, plays a critical role in subthreshold excitability and can influence action potentials when its current amplitude increases.