Publications by authors named "Chizuko Yonekawa"
Structure-based design of UDP-GlcNAc analogs as candidate GnT-V inhibitors.
Biochim Biophys Acta Gen Subj
June 2022
Article Synopsis
- N-Glycan branching influences glycoprotein functions, with N-Acetylglucosaminyltransferase V (GnT-V) being crucial in cancer progression, prompting the search for specific GnT-V inhibitors as potential cancer therapies.
- Researchers synthesized 10 UDP-GlcNAc analogs, modifying their phosphate groups to introduce hydrophobic features, and developed an HPLC-based assay to evaluate how these compounds inhibited GnT-V compared to other glucosaminyltransferases.
- The study found modest inhibition of GnT-V by several analogs, indicating a preference for GnT-V, and suggested that this approach of modifying donor substrates could lead to the development of selective GnT-V inhibitors, offering new
Fucosylated glycans critically regulate the physiological functions of proteins and cells. Alterations in levels of fucosylated glycans are associated with various diseases. For detection and functional modulation of fucosylated glycans, chemical biology approaches using fucose (Fuc) analogs are useful.
View Article and Find Full Text PDFRegion-specific upregulation of HNK-1 glycan in the PRMT1-deficient brain.
Biochim Biophys Acta Gen Subj
March 2020
Background: Brains express structurally unique glycans, including human natural killer-1 (HNK-1), which participate in development and high-order functions. However, the regulatory mechanisms of expression of these brain-specific glycans are largely unknown. We examined whether arginine methylation, another type of protein modification essential for neural development, impacts the expression of various glycans in the developing brain.
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