The use of artrofoon in the treatment of ankylosing spondyloarthritis.

In patients with ankylosing spondyloarthritis, artrofoon produced a more potent antiinflammatory effect than nonsteroidal antiinflammatory drugs. The study demonstrated a positive effect of artrofoon on clinical and laboratory parameters, good tolerability of the preparation, and the absence of negative effects on the hepatic and renal functions. Being added to complex therapy, artrofoon led to a decrease in the dose of nonsteroidal antiinflammatory drugs.

[Resistance of herpes simplex virus to acyclovir: laboratory and clinical aspects].

Clinical isolates of the Herpes simplex virus had different susceptibility to acyclovir. Along with highly susceptible variants there were often isolated resistant variants and variants with intermediate susceptibility to the drug. All the clinical isolates were from the patients previously not treated with acyclovir.

[The role of immunocytes in the production of interferon in response to its induction by aromatic hydrocarbons].

Interferon (IF) was synthesized in animals by diverse populations of immunocytes in response to induction by various low molecular weight aromatic hydrocarbons. The level of the involvement of either population of the immunocytes in IF production is determined by the chosen inductor. IF induction by acridanone L-1 was mainly observed in macrophages and B-lymphocytes.

[The efficacy of ribamidil in experimental RS-virus infection].

The antiviral activity of a national analogue of virasol, ribamydil, with regard to RS virus infection was studied in tissue culture and in experimental animals. In L-41 cell cultures ribamydil in a dose of 60 micrograms/ml or more completely inhibited multiplication of RS virus strain Long, in a titre of 4.75 lg CPD50.

[The comparative characteristics of the interferon-inducing capacity of 2 preparations related to aromatic hydrocarbons].

Aromatic hydrocarbons are rightly considered to belong to most active synthetic interferon inducers among low molecular compounds. A comparative evaluation of L-1 (acridanon) and amixin (fluorenon) showed L-1 to have more marked interferon-inducing properties. Both compounds differed not only in the dynamics and levels of interferon synthesis in different organs which suggests the possibility of their employment in different diseases, but also in the efficacy of the modes of application.

[Clinical research on the tolerance for and the interferon-inducing activity of amiksin].

Tolerance and interferon-inducing activity of amixine, an interferon inducer, was studied by the double-blind method clinically in healthy volunteers given tableted amixine orally in doses of 0.125-0.25 g by different schedules.

[Molecular mechanisms of the antiviral activity of nucleoside analogs].

The latest data are reviewed on the molecular biology mechanisms of antiviral effect exhibited by the analogues of nucleic acids components. Main effects of preparations used in medicine and virology are analyzed. The data are presented in proof of the existence of different as well as common pathways for virus inhibiting effects of different preparations.

[Model of experimental Pixuna infection in white mice].

The results of the development of a nonfatal model of experimental infection induced by Pixuna alpha-virus and suitable for the evaluation of the effectiveness of antiviral drugs are described. The asymptomatic infection induced in white mice by intranasal inoculation of Pixuna virus is characterized by intensive virus multiplication in the brain and spleen of the animals. In these organs virus reproduction is observed early after infection and amplification of the agent reaches maximum titres within 72 h postinfection.

[Evaluation of the inhibiting action of virazole on the reproduction of the vaccinia virus in tissue culture].

Experimental data of the evaluation of the antiviral activity of virazole in tissue culture using the fluorescent antibody technique are presented. Administration of virazole in the maintenance medium in a concentration range of 800--6.25 microgram/ml immediately after vaccinia virus adsorption exerts a marked inhibiting effect reducing virus reproduction by 3.