Publications by authors named "Chiyuki Takeda"
Study on enteral nutrient components causing decreased gastric phenytoin absorption.
JPEN J Parenter Enteral Nutr
September 2023
Article Synopsis
- Coadministration of certain enteral nutrients (ENs) negatively impact the absorption of the antiepileptic drug phenytoin (PHT), but the underlying mechanisms remain unclear.
- Researchers used a model with Caco-2 cells to investigate how different nutrients affect the permeability of PHT, finding that casein, digested soy protein, and dextrin significantly reduced its absorption, while digested casein had the opposite effect.
- The study concludes that the composition of ENs can influence PHT absorption, which is crucial for determining the best ENs to use alongside oral PHT treatment.