Feasibility Study on Optimising the Efficacy of a Population Age Estimation Model for South China by Combined Machine Learning for the Second and Third Molars.

Dental age estimation, as an important part of forensic anthropology, has a wide range of applications for its results in legal practice. Given the lowered legal age for criminal responsibility in China and the increasing juvenile delinquency, we establish a morphological database targeting the second (M2) and third molars (M3) of the Southern Chinese population. Full mouth orthopantomography from 1486 individuals aged 8.

Identifying piRNAs that regulate BaP-induced lung injuries: A bottom-up approach from toxicity pathway investigation to animal validation.

PIWI-interacting RNAs (piRNAs) is an emerging class of small non-coding RNAs that has been recently reported to have functions in infertility, tumorigenesis, and multiple diseases in humans. Previously, 5 toxicity pathways were proposed from hundreds of toxicological studies that underlie BaP-induced lung injuries, and a "Bottom-up" approach was established to identify small non-coding RNAs that drive BaP-induced pulmonary effects by investigating the activation of these pathways in vitro, and the expression of the candidate microRNAs were validated in tissues of patients with lung diseases from publications. Here in this study, we employed the "Bottom-up" approach to identifying the roles of piRNAs and further validated the mechanisms in vivo using mouse acute lung injury model.