Dietary macronutrient composition and its effect on 24-h substrate oxidation: A study of diurnal variations in carbohydrate and fat intake.

Background & Aims: In recent times, the complexity of food styles and meal content has increased, leading to significant variations in macronutrient composition between meals. This phenomenon has coincided with a rise in obesity rates. We aimed to determine whether a large variation in macronutrient composition between meals results in reduced fat oxidation.

Healthy Japanese dietary pattern is associated with slower biological aging in older men: WASEDA'S health study.

Aging is the greatest risk factor for numerous diseases and mortality, and establishing geroprotective interventions targeting aging is required. Previous studies have suggested that healthy dietary patterns, such as the Mediterranean diet, are associated with delayed biological aging; however, these associations depend on nationality and sex. Therefore, this study aimed to investigate the relationship between dietary patterns identified through principal component analysis and biological aging in older men of Japan, one of the countries with the longest life expectancies.

Associations between cardiorespiratory fitness and lifestyle-related factors with DNA methylation-based ageing clocks in older men: WASEDA'S Health Study.

DNA methylation-based age estimators (DNAm ageing clocks) are currently one of the most promising biomarkers for predicting biological age. However, the relationships between cardiorespiratory fitness (CRF), measured directly by expiratory gas analysis, and DNAm ageing clocks are largely unknown. We investigated the relationships between CRF and the age-adjusted value from the residuals of the regression of DNAm ageing clock to chronological age (DNAmAgeAcceleration: DNAmAgeAccel) and attempted to determine the relative contribution of CRF to DNAmAgeAccel in the presence of other lifestyle factors.

Fat-Free Mass Index as a Surrogate Marker of Appendicular Skeletal Muscle Mass Index for Low Muscle Mass Screening in Sarcopenia.

Objectives: We aimed to examine the relationship between the fat-free mass index (FFMI; FFM/height) and appendicular skeletal muscle mass index (ASMI; ASM/height), measured using both bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA), and investigate the effects of age and obesity. We also evaluated the suitability of BIA-measured FFMI as a simple surrogate marker of the ASMI and calculated the optimal FFMI cutoff value for low muscle mass screening to diagnose sarcopenia.

Design: Cross-sectional study.

Coffee consumption and skeletal muscle mass: WASEDA'S Health Study.

Few studies have examined the association between coffee consumption and muscle mass; their results are conflicting. Therefore, we examined the association between coffee consumption and low muscle mass prevalence. We also performed an exploratory investigation of the potential effect modification by demographic, health status-related and physical activity-related covariates.

Association Between Dietary Patterns and Different Metabolic Phenotypes in Japanese Adults: WASEDA'S Health Study.

Although many studies have reported that a posteriori dietary pattern is associated with metabolic health, there is little evidence of an association between dietary patterns and different metabolic phenotypes. The present study aimed to examine the association between major dietary patterns and different metabolic phenotypes (metabolically healthy non-obese [MHNO], metabolically unhealthy non-obese [MUNO], metabolically healthy obese [MHO], and metabolically unhealthy obese [MUO]) in middle-aged and elderly Japanese adults. This cross-sectional study enrolled 2,170 Japanese adults aged ≥40 years.

Development and validation of a simple anthropometric equation to predict appendicular skeletal muscle mass.

Background & Aims: A limited number of studies have developed simple anthropometric equations that can be implemented for predicting muscle mass in the local community. Several studies have suggested calf circumference as a simple and accurate surrogate maker for muscle mass. We aimed to develop and cross-validate a simple anthropometric equation, which incorporates calf circumference, to predict appendicular skeletal muscle mass (ASM) using dual-energy X-ray absorptiometry (DXA).

Association between alcohol dietary pattern and prevalence of dyslipidaemia: WASEDA'S Health Study.

The association between a dietary pattern characterised by high alcohol intake and dyslipidaemia has not been fully investigated. Therefore, the present study aimed to investigate the association between alcohol dietary patterns and the prevalence of dyslipidaemia and its components. This cross-sectional study enrolled 2171 men and women aged ≥40 years who were alumni of a Japanese university.

Determinants of Resting Oxidative Stress in Middle-Aged and Elderly Men and Women: WASEDA'S Health Study.

Previous studies have not investigated the determinants of resting oxidative stress, including physical fitness, as it relates to redox regulation. The present study therefore was aimed at identifying lifestyle and biological factors that determine resting oxidative stress, including objectively measured physical fitness. In 873 middle-aged and elderly men and women, age and anthropometric parameters, lifestyle-related parameters, medication and supplementation status, physical fitness, biochemical parameters, and nutritional intake status, as well as three plasma oxidative stress markers: protein carbonyl (PC), F-isoprostane (F-IsoP), and thiobarbituric acid reactive substances (TBARS), were surveyed and measured.

Visceral fat and cardiorespiratory fitness with prevalence of pre-diabetes/diabetes mellitus among middle-aged and elderly Japanese people: WASEDA'S Health Study.

The relationships between cardiorespiratory fitness (CRF) measurements not confounded by adiposity and the prevalence of pre-diabetes mellitus (pre-DM) and diabetes mellitus (DM) are not well known. Thus, we aimed to investigate the associations of visceral fat (VF) and CRF with the prevalence of pre-DM/DM among Japanese adults. The study included 970 individuals (327 women and 643 men) who were 40-87 years old and had complete health examinations, abdominal fat area, and fitness data from WASEDA'S Health Study during 2015-2018.

Cut-offs for calf circumference as a screening tool for low muscle mass: WASEDA'S Health Study.

Aim: To re-evaluate the suitability of calf circumference as a surrogate marker of low muscle mass measured by both bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA). We also examined the effects of obesity and age on low muscle mass screening using calf circumference.

Methods: In total, 1239 adults participated in this cross-sectional study.

Simple Prediction of Metabolic Equivalents of Daily Activities Using Heart Rate Monitor without Calibration of Individuals.

Background: Heart rate (HR) during physical activity is strongly affected by the level of physical fitness. Therefore, to assess the effects of fitness, we developed predictive equations to estimate the metabolic equivalent (MET) of daily activities, which includes low intensity activities, by % HR reserve (%HRR), resting HR, and multiple physical characteristics.

Methods: Forty volunteers between the ages of 21 and 55 performed 20 types of daily activities while recording HR and sampling expired gas to evaluate METs values.

Micronutrient Intake Adequacy in Men and Women with a Healthy Japanese Dietary Pattern.

This study examined the relationship between a healthy Japanese dietary pattern and micronutrient intake adequacy based on the Dietary Reference Intakes for Japanese 2015 (DRIs-J 2015) in men and women. A cross-sectional study was conducted in 1418 men and 795 women aged 40-87 years, who participated in the Waseda Alumni's Sports, Exercise, Daily Activity, Sedentariness, and Health Study. Dietary patterns were derived from principal component analysis of the consumption of 52 food and beverage items, which were assessed by a validated brief-type self-administered diet history questionnaire.

Validity of estimating physical activity intensity using a triaxial accelerometer in healthy adults and older adults.

Background: A triaxial accelerometer with an algorithm that could discriminate locomotive and non-locomotive activities in adults has been developed. However, in the elderly, this accelerometer has not yet been validated. The aim were to examine the validity of this accelerometer in the healthy elderly, and to compare the results with those derived in a healthy younger sample.

Prediction of Physical Activity Intensity with Accelerometry in Young Children.

: An algorithm for the classification of ambulatory and non-ambulatory activities using the ratio of unfiltered to filtered synthetic acceleration measured with a triaxial accelerometer and predictive models for physical activity intensity (METs) in adults and in elementary school children has been developed. The purpose of the present study was to derive predictive equations for METs with a similar algorithm in young children. : Thirty-seven healthy Japanese children (four- to six-years old) participated in this study.

Estimating metabolic equivalents for activities in daily life using acceleration and heart rate in wearable devices.

Background: Herein, an algorithm that can be used in wearable health monitoring devices to estimate metabolic equivalents (METs) based on physical activity intensity data, particularly for certain activities in daily life that make MET estimation difficult.

Results: Energy expenditure data were obtained from 42 volunteers using indirect calorimetry, triaxial accelerations and heart rates. The proposed algorithm used the percentage of heart rate reserve (%HRR) and the acceleration signal from the wearable device to divide the data into a middle-intensity group and a high-intensity group (HIG).

Effect of diurnal variations in the carbohydrate and fat composition of meals on postprandial glycemic response in healthy adults: a novel insight for the second-meal phenomenon.

Background: Meals, particularly carbohydrate intake, determine diurnal blood glucose (BG) excursions. However, the effect of meals with variable carbohydrate content on diurnal BG excursions remains poorly understood, despite routine consumption of meals that vary daily.

Objective: The aim of this study was to verify our hypothesis that glycemic response is elevated when a meal with a higher carbohydrate content follows a meal with a lower carbohydrate content.

Physical activity group classification algorithm using triaxial acceleration and heart rate.

As described in this paper, a physical activity classification algorithm is proposed for energy expenditure estimation. The proposed algorithm can improve the classification accuracy using both the triaxial acceleration and heart rate. The optimal classification also contributes to improvement of the accuracy of the energy expenditures estimation.

Validity and reproducibility of a novel method for time-course evaluation of diet-induced thermogenesis in a respiratory chamber.

We developed a novel method for computing diet-induced thermogenesis (DIT) in a respiratory chamber and evaluated the validity and reproducibility of the method. We hypothesized that DIT may be calculated as the difference between postprandial energy expenditure (EE) and estimated EE (sum of basal metabolic rate and physical activity (PA)-related EE). The estimated EE was derived from the regression equation between EE from respiration and PA intensity in the fasting state.

Effects of intermittent physical activity on fat utilization over a whole day.

Purpose: We examined whether continuous and intermittent physical activity (PA) differentially influence fat utilization.

Methods: This was a randomized crossover study. Nine healthy young male participants performed two 39-h (two nights, three days) PA sessions (continuous and intermittent exercise) in a respiratory chamber to measure energy expenditure (EE) and substrate oxidation.

Characteristics of body composition and resting energy expenditure in lean young women.

The number of lean young women has been increasing. Fear of being fat may induce unnecessary attempts to reduce body weight, which can cause several types of illness. Many investigations have demonstrated dysfunction of the hypothalamus and metabolic differences in patients with anorexia nervosa.

Resting energy expenditure can be assessed by fat-free mass in female athletes regardless of body size.

Energy requirements can be estimated from resting energy expenditure (REE). However, little is known about factors influencing REE in Japanese female athletes. This study was performed to evaluate the relationship between REE and body composition in Japanese female athletes with a wide range of body sizes.

Visceral fat is a strong predictor of insulin resistance regardless of cardiorespiratory fitness in non-diabetic people.

Abdominal adiposity and low cardiorespiratory fitness are associated with insulin resistance in people with impaired glucose tolerance and type 2 diabetes. However, little is known about which factor precedes insulin resistance in people with impaired glucose tolerance and type 2 diabetes, and which is the stronger predictor of insulin resistance in non-diabetic people. The purpose of this study was to examine the relationship between insulin resistance and cardiorespiratory fitness, visceral fat, and subcutaneous fat in non-diabetic people.

Elderly oarsmen have larger trunk and thigh muscles and greater strength than age-matched untrained men.

To evaluate whether regularly performed rowing exercise affects the trunk muscles size and function, and to examine the effect of rowing exercise on thigh muscle size and function in elderly rowers, we compared the cross-sectional area (CSA) and strength of these muscles in elderly male rowers and in age-matched untrained men. Participants were 16 elderly rowing-trained men (ROW age, 67.8 +/- 2.