Publications by authors named "Chiyoko Terada-Ikeda"
A Disintegrin and Metalloproteinase with Thrombospondin Motifs 4 Regulates Pulmonary Vascular Hyperpermeability through Destruction of Glycocalyx in Acute Respiratory Distress Syndrome.
Int J Mol Sci
November 2023
Acute respiratory distress syndrome (ARDS) has no specific and effective treatment, and there is an urgent need to understand its pathogenesis. Therefore, based on the hypothesis that molecules whose expression is upregulated in injured pulmonary vascular endothelial cells (VECs) are involved in the pathogenesis of ARDS, we conducted a study to elucidate the molecular mechanisms and identify target factors for treatment. Primary human lung microvascular endothelial cells (HMVEC-Ls) were stimulated with lipopolysaccharide (LPS) or poly (I:C) and analyzed via a microarray to identify target genes for ARDS.
View Article and Find Full Text PDFIntroduction: Acute respiratory distress syndrome (ARDS) is a severe hypoxemic respiratory failure with a high in-hospital mortality. However, the molecular mechanisms underlying ARDS remain unclear. Recent findings have indicated that the onset of severe inflammatory diseases, such as sepsis, is regulated by epigenetic changes.
View Article and Find Full Text PDFArticle Synopsis
- Bifidobacterium breve M-16V is a probiotic strain that can help balance immune responses, particularly useful for infants suffering from allergies.
- A study showed that feeding pregnant mice this probiotic reduced asthma-related inflammation in their newborns exposed to air pollution, indicated by fewer eosinophils and lower levels of certain Th2 cytokines.
- Additionally, the probiotic altered the gut microbiota in the newborns, potentially contributing to the reduction of allergic reactions linked to air pollution exposure.