Publications by authors named "Chiyoko Nohara"
Article Synopsis
- Satralizumab, an antibody approved in Japan for preventing relapses in NMOSD, is being evaluated for its real-world safety and effectiveness through ongoing post-marketing surveillance, with an interim analysis covering data from August 2020 to July 2021.
- The study involved 570 participants, mostly female (91.75%), with a mean age of 52.4 years; notable findings included a treatment discontinuation rate of 14.91% and adverse drug reactions occurring in 20.70% of patients, particularly infections.
- Results showed a significant reduction in glucocorticoid usage and a high relapse-free rate of 94.59% at 6 months, indicating that satralizumab
Unlabelled: Neurogenic orthostatic hypotension (OH) causes severe orthostatic intolerance. We evaluated hemodynamic parameters in a patient with pure autonomic failure (PAF) using various unique approaches. A 60-year-old woman had worsening light-headedness, fatigue, and severe OH without compensatory tachycardia.
View Article and Find Full Text PDFAims: Multiple sclerosis (MS) is a disabling autoimmune disease affecting the central nervous system. Few studies have examined the effect of MS on patient outcomes in Japan. The study aim was to quantify MS burden in Japan by comparing MS respondents to matched controls on patient outcomes.
View Article and Find Full Text PDFSeventy-seven cases of the optic-spinal form of multiple sclerosis (OSMS) were collected from 6 institutes in 3 cities of Japan, and the clinical and MRI features were analyzed. Two-thirds of the OSMS patients had longitudinally extensive spinal cord MRI lesions (LESL), and had clinical features similar to those of relapsing neuromyelitis optica which often causes severe disability. In contrast, OSMS patients without LESL tended to have milder disease and had some feature commonly seen in the conventional form of MS.
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