Publications by authors named "Chiyo Oishi"
Article Synopsis
- This study investigates the roles of caspase-8 and -9 in drug-induced liver injury (DILI) caused by CYP2E1 metabolites using rat models and human liver cell cultures exposed to carbon tetrachloride, halothane, and sevoflurane.
- In vivo results showed no liver dysfunction after sevoflurane exposure, but carbon tetrachloride and halothane led to increased liver damage indicators and caspase activities, indicating hepatotoxicity in both studies.
- CYP2E1-related compounds significantly contribute to the toxicity of halogenated hydrocarbons, suggesting that monitoring caspase-8 and -9 activities could serve as new
