Infiltration by macrophages and lymphocytes in transplantable mouse sarcoma after irradiation with high-intensity focused ultrasound.

Background: High-intensity focused ultrasound (HIFU) therapy offers great promise for the treatment of cancer. The histological changes, including the antitumor immunological response, after HIFU treatment was examined in soft tissue sarcoma.

Materials And Methods: Sarcoma 180 cells were injected subcutaneously in mice.

The sonodynamic antitumor effect of methylene blue on sarcoma180 cells in vitro.

Background: Sonodynamic therapy (SDT) is a promising methodology for cancer treatment. Methylene blue (MB) is a phenothiazine dye that is widely used in clinical practice and can be administered intravenously.

Materials And Methods: The sonodynamic antitumor effect of 1, 10 and 100 microM MB on sarcoma180 (S180) cells was investigated in vitro.

Sonodynamic effects of lomefloxacin derivatives conjugated with methoxy polyethylene glycol on sarcoma 180 cells.

Background: Sonodynamic therapy (SDT) is a promising methodology for cancer treatment. Lomefloxacin hydrochloride (LFLX) has been reported to have sonodymamic antitumor effects.

Materials And Methods: We synthesized LFLX derivatives conjugated with methoxy polyethylene glycol (PEGylated LFLXs) and investigated their ultrasonically induced antitumor effects.

Antitumor effect of acridine orange under ultrasonic irradiation in vitro.

Background: Sonodynamic synergistic antitumor therapy is a promising new methodology for cancer treatment.

Materials And Methods: To determine the antitumor effects of ultrasound (US) in the presence of acridine orange (AO), 1.0 microg/ml solution of AO was tested as a sonodynamic compound against sarcoma 180 cells in vitro.

Enhanced antitumor activity of ultrasonic irradiation in the presence of new quinolone antibiotics in vitro.

To determine if there is any synergistic antitumor effect of ultrasound (US) in the presence of new quinolone (NQ) antibiotics, 0.2 mM solutions of lomefloxacin hydrochloride (LFLX), sparfloxacin (SPFX), ciprofloxacin hydrochloride (CPFX), and gatifloxacin hydrate (GFLX) were tested as sonodynamic agents against sarcoma 180 cells in vitro. After US irradiation at 2 W/cm(2) for 30 and 60 s, the survival rates of tumor cells in the presence of NQ antibiotics were significantly lower than those in their absence (P < 0.

Ultrastructure of sarcoma 180 cells after ultrasound irradiation in the presence of sparfloxacin.

Background: Sonodynamic synergistic antitumor effects have been well described to date, but detailed ultrastructural studies in this field are still lacking.

Materials And Methods: A suspension of sarcoma 180 cells was exposed to ultrasound (US) in the presence of sparfloxacin (SPFX), one of the new quinolone antibiotics, at 2 W (0.64 W/cm2) for 30 seconds.