SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids.

SARS-CoV-2 provokes devastating tissue damage by cytokine release syndrome and leads to multi-organ failure. Modeling the process of immune cell activation and subsequent tissue damage is a significant task. Organoids from human tissues advanced our understanding of SARS-CoV-2 infection mechanisms though, they are missing crucial components: immune cells and endothelial cells.

Organoids in COVID-19: can we break the glass ceiling?

COVID-19 emerged in September 2020 as a disease caused by the virus SARS-CoV-2. The disease presented as pneumonia at first but later was shown to cause multisystem infections and long-term complications. Many efforts have been put into discovering the exact pathogenesis of the disease.

Fabrication of spatial modulated second order nonlinear structures and quasi-phase matched second harmonic generation in a poled azo-copolymer planar waveguide.

This work demonstrates that arbitrary types of spatially modulated second-order susceptibility (chi((2)) structures such as 1D and 2D, periodic and quasi-periodic structures can be obtained by using the combination of corona poling and direct laser writing (DLW) techniques. The fabrication technique is based on the photodepoling of azo-dye molecules caused by one-photon or two-photon absorption during the DLW process. Polarization and second harmonic generation (SHG) images of the fabricated structures were measured by electrostatic force microscope and SHG mapping techniques, respectively.

Determination of 24 minor red blood cell antigens for more than 2000 blood donors by high-throughput DNA analysis.

Background: A "BeadChip" array permits reliable simultaneous DNA typing of single-nucleotide polymorphisms for minor blood groups. A high-throughput DNA analysis was studied as a routine method of phenotype prediction and software was developed to interpret and analyze the large volume of data points.

Study Design And Methods: DNA was extracted from whole blood of donors of known phenotypes and self-identified ethnicity.