DigiLoCS: A leap forward in predictive organ-on-chip simulations.

Digital twins, driven by data and mathematical modelling, have emerged as powerful tools for simulating complex biological systems. In this work, we focus on modelling the clearance on a liver-on-chip as a digital twin that closely mimics the clearance functionality of the human liver. Our approach involves the creation of a compartmental physiological model of the liver using ordinary differential equations (ODEs) to estimate pharmacokinetic (PK) parameters related to on-chip liver clearance.

Distinct pathoclinical clusters among patients with uncontrolled type 2 diabetes: results from a prospective study in rural India.

Introduction: Inadequate glycemic control among patients with type 2 diabetes mellitus (T2DM) poses an enormous challenge. Whether this uncontrolled T2DM population is a heterogenous mix of disease subtypes remains unknown. Identification of these subtypes would result in a customized T2DM management protocol thereby paving the way toward personalized therapy.

Clustering Based Parameter Estimation of Thyroid Hormone Pathway.

An ordinary differential equation (ODE) model of the working of the thyroid system for euthyroidism has been presented. As clinical data for thyroid hormones is relatively scarce, such modelling offers potential benefits over wet lab procedures. Genetic algorithms developed for determining of parameters of the ODE system using the available data have been presented and evaluated.