Publications by authors named "Chitra Thyagaraju"

Background: Many studies in India and all over the world have focused on the psychological aspect of infertility in women, but only a few have explored it among men. To deal with psychological distress, sometimes, individuals may use maladaptive coping strategies which can further worsen the stress instead of reducing it.

Aim: To assess symptoms of depression, anxiety, stress, and various coping strategies adopted by men with infertility along with exploring their coping experiences.

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Background: Thyroid auto-antibodies could be one of the many causes of infertility in women, especially with polycystic ovarian syndrome (PCOS) with a prevalence of 5%-15%. Patients with anti-thyroid antibodies have shown significantly lower fertilisation rates, implantation rates, lower pregnancy rates and increased risk of first-trimester abortions when compared with those without anti-thyroid antibodies.

Aim: The aim of the study was to assess the prevalence of thyroid auto-antibodies in euthyroid infertile women with PCOS and to compare the prevalence of thyroid autoantibodies in euthyroid infertile women with PCOS and without PCOS.

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Background: Polycystic ovary syndrome (PCOS) is known to be associated with metabolic syndrome (MS). It is characterised by insulin resistance, hyperinsulinemia, dyslipidemia, obesity and hypertension. Data related to MS in infertile women with PCOS are limited in Indian populations.

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Introduction: Endometrial injury (ES) has been suggested as intervention to increase probability of pregnancy in women undergoing assisted reproductive technologies. Majority of studies reported that ES improves outcome in Invitro fertilisation,Intrauterine Insemination(IUI) and natural conceptions: however, the size and quality of studies are poor which questions the presence of any beneficial effect. The present study was done to evaluate the effect of endometrial scratching on pregnancy rate after previous failed Intrauterine Insemination and to assess the pain and bleeding following the procedure.

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Background: Even though angiopoeitin-2 and interleukin (IL)-23 are known to be altered in polycystic ovary syndrome (PCOS), their association with clomiphene citrate (CC) resistance has not been studied.

Aim: The objective of the study was to investigate whether angiopoietin-2 levels are associated with inflammation and CC resistance in PCOS.

Settings And Design: This study was conducted in a tertiary care hospital.

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Article Synopsis
  • A study investigated the impact of organophosphate (OP) pesticide exposure on sperm quality in Southern Indian men with abnormal semen analysis, finding a significant correlation between OP exposure and lower sperm quality.* -
  • The research involved 50 men with abnormal semen analysis and 50 control men, measuring their OP pesticide exposure through biochemical markers and urine metabolites.* -
  • Results indicated that men with abnormal semen had lower enzyme levels related to OP exposure and higher urinary presence of pesticide metabolites, suggesting a detrimental effect on sperm motility and overall quality.*
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Background: Laparoscopic cystectomy is one of the common modes of treatment for benign ovarian cysts. The data related to the effect of cystectomy on ovarian reserve are limited.

Aim: The aim of this study was to investigate the effect of laparoscopic ovarian cystectomy on anti-Mullerian hormone (AMH) levels in benign ovarian cysts.

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Background: Matrix metalloproteinase-9 (MMP-9), interleukin-17 (IL-17) and psychological stress are known to play a role in the pathogenesis of male infertility.

Objective: To assess the association of MMP-9 with IL-17 and psychological stress in infertile men.

Materials And Methods: In this cross-sectional study, 39 men with infertility diagnosed based on semen analysis and 39 subjects with normal semen analysis were included in the study.

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Background: Laparoscopic ovarian drilling (LOD) is one of the common modes of treatment for women with polycystic ovary syndrome (PCOS) who are resistant to clomiphene citrate. The data related to the effect of LOD on sex hormones are limited.

Aim: The objective of the study was to investigate the effect of LOD on hormonal parameters and clinical outcomes in women with PCOS.

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Objectives: Matrix metalloproteinase-9, Nitric oxide and inflammation plays a role in the pathogenesis of poly cystic ovary syndrome (PCOS). Even though these parameters are altered in PCOS, the effect of clomiphene citrate on them has not been studied till date. The present study was done to assess the effect of clomiphene citrate on matrix metalloproteinase-9, nitric oxide and interleukin-10 levels in women with PCOS.

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