Publications by authors named "Chitra Pathirana"

Background: Effective β-cell regeneration is a recognized therapeutic strategy in the treatment of type 1 diabetes mellitus. Regeneration of β-cells could be achieved via exogenous natural sources as medicinal plant extracts. Medicinal plants selected for the investigation were Spondias pinnata (Linn.

View Article and Find Full Text PDF

Gmelina arborea Roxb. (common name: Et-demata, Family: Verbenaceae) has been used traditionally in Sri Lanka as a remedy against diabetes mellitus. The objective of the present study was to evaluate antidiabetic mechanisms of the aqueous bark extract of G.

View Article and Find Full Text PDF

Objective: There is limited data on the assessment of relationship between sex hormones, metabolic syndrome (MS) and inflammation. Therefore, our objective was to examine the relationship between metabolic syndrome, testosterone and inflammation.

Patients And Methods: It was a cross-sectional study which included 309 subjects in the age range of 30-70years.

View Article and Find Full Text PDF

Context: Low testosterone levels are associated with an atherogenic lipid profile and may contribute to the pathogenesis of atherosclerosis.

Aims: Our study aimed to investigate the relationship between serum total testosterone (TT) levels and lipid profile in angiographically confirmed coronary artery disease (CAD) in men.

Settings And Design: This is a case-control hospital-based study at Teaching Hospital, Karapitiya, Galle, Sri Lanka.

View Article and Find Full Text PDF

Background: Diabetes mellitus, for a long time, has been treated with plant derived medicines in Sri Lanka.

Aim: The aim of this study is to determine the efficacy and dose response of oral antihyperglycaemic activity of eight Sri Lankan medicinal plant extracts, which are used to treat diabetes in traditional medicine in diabetic rats.

Materials And Methods: Medicinal plants selected for the study on the basis of documented effectiveness and wide use among traditional Ayurveda physicians in the Southern region of Sri Lanka for the treatment of diabetes mellitus.

View Article and Find Full Text PDF