Regioselective allenylation and propargylation of various -quinone methides using alkynyl azaarenes as pronucleophiles.

We have developed Brønsted base-mediated regioselective allenylation and propargylation of various -quinone methides using unfunctionalized 2-alkynyl azaarenes as pronucleophiles. The appropriate choice of a base provides an opportunity to achieve either an allenylated product or the propargylated product. The use of KOBu as a Brønsted base promotes the formation of allenylated products, whereas NaN(SiMe) furnishes the propargylated products.

Palladium-Catalyzed Direct C2-Biarylation of Indoles.

Biaryl and indole units are important structural motifs in several bioactive molecules and functional materials. We have accomplished straightforward access to C2-biarylated indole derivatives through palladium-catalyzed C-H activation strategy with a broad range of substrate scope in yields of 24 to 92%. Besides, the UV/visible absorption and fluorescence properties of the ensuing products were explored.