Publications by authors named "Chithra M Muthuramu"
Article Synopsis
- Protein arginine deiminases (PAD) are linked to inflammatory diseases like multiple sclerosis (MS), prompting research into new inhibitors.
- Researchers designed thirteen compounds based on a hydantoin structure, focusing on a specific modification to enhance PAD inhibitory activity.
- Two compounds, particularly one with an imidazole moiety, showed strong inhibition of PAD enzymes and effective reduction of disease symptoms in both in vitro and in vivo mouse models of MS.
