Publications by authors named "Chithra Chittybabu"
Psychiatr Genet
December 2014
Article Synopsis
- Clozapine is an antipsychotic used for treatment-resistant schizophrenia but can cause side effects like sialorrhea (excessive salivation), affecting many patients.
- A study involving 95 patients explored whether a specific genetic variation (a 120-bp duplication in the DRD4 gene) is linked to the occurrence of sialorrhea caused by clozapine.
- Results showed a significant association between the DRD4 polymorphism and the development of sialorrhea, indicating that patients with the duplication are nearly three times more likely to experience this side effect while on clozapine.
