Publications by authors named "Chithirachelvi Vasudevan"
Resident tissue macrophages (RTMs) develop from distinct waves of embryonic progenitor cells that seed tissues before birth. Tissue-specific signals drive a differentiation program that leads to the functional specialization of RTM subsets. Genetic programs that regulate the development of RTMs are incompletely understood, as are the mechanisms that enable their maintenance in adulthood.
View Article and Find Full Text PDFIntestinal microbes influence development of thymic lymphocytes in early life.
Proc Natl Acad Sci U S A
February 2020
Article Synopsis
- The thymus is responsible for producing T cells, with their development regulated by specific transcription factors and influenced by gut microbiota during early life.
- Research shows that gut microbes affect the balance of certain T cell types in the thymus, highlighting the role of intestinal flora in immune system development.
- Changes in thymic T cell populations due to early microbial exposure can have lasting impacts, potentially increasing vulnerability to immune-related diseases in adulthood.