Proinflammatory mediators and reproductive failure in women with uterine fibroids.

Objective: study the levels of proinflammatory mediators and their correlation with reproductivefailure in women with uterine fibroids (UF).

Materials And Methods: 90 women aged 18 - 45 years (mean age - 33.9 ± 0.

How noninvasive treatment of uterine fibroids affects endometrial receptivity: a prospective cohort study.

Objective: To investigate the effect of the ultrasonic energy during MRI-guided high-intensity focused ultrasound ablation (HIFU) of uterine fibroids on molecular and tissue markers of endometrial receptivity in women of reproductive age.

Material And Methods: A prospective cohort study of 60 women of reproductive age was conducted. The main group consisted of 32 patients suffering from the symptomatic course of uterine fibroids who received treatment with HIFU ablation of uterine fibroids.

[Congenital giant melanocytic nevi].

The paper describes a case of a rare tumor disease with massive involvement of the skin, mainly that of the occipital head and brain and liver tissues in a newborn infant. It considers the morphological and immunohistochemical characteristics of a giant tumor cell nidus in the skin of the occipital head.

Ultrastructural markers of tissue endometrial receptivity in patients with recurrent implantation failure.

The scanning electron microscopy of the endometrial surface epithelium during the 'implantation window' was performed in 119 patients with uterine factor of infertility or recurrent miscarriage due to endometrial hypoplasia. Ultramorphological picture of the surface endometrial epithelium was characterized by aplasia and hypoplasia of pinopodes (67.39%), dense cell - cell contacts (69.

[The phenotypic and functional characteristics of cells of inherent and adaptive immunity of newborns of various gestation age.].

During last years, a large number of studies related to investigation of development of immune system at early stages of ontogenesis are directed to expansion of concepts of mechanisms of inherent and adaptive immunity in premature newborns. However, discrepancy in publication data and absence of accurate conceptions about condition of immune system in children of various gestation age determine actuality of further investigation of this problem. The study was carried out to establish characteristics of phenotypic and functional characteristics of cells of inherent and adaptive immunity.

Risk factors vary early preterm birth and perinatal complications after assisted reproductive technology.

We conducted a study of markers of endothelial dysfunction and angiogenesis regulation, as well as the identification of the main lymphocyte populations, activated CD3  CD95-cells and cytokine-producing CD4  IFN-γ-, CD4  IL-4-lymphocytes in the 1st trimester of gestation in women with ART-induced pregnancy and spontaneous pregnancy. We used the same indicators to assess the immune status of ELBW infants at birth and at the post-conceptual age of 38-40 weeks. It was determined that the risk factors of very early preterm delivery are: threatened miscarriage, chronic placental insufficiency, endothelial dysfunction, increased spontaneous production of intracellular cytokines.

Characterization of blood flow rate in dental pulp by speckle patterns of backscattered light from an in vivo tooth.

Experimental data on the hemodynamics of dental pulp at different stages of caries treatment are given. Observations of speckle patterns in backscattered laser light are used as a measurement method to qualitatively characterize changes in blood flow rate through the dental pulp. The measurements were made by the author-designed experimental setup.

Immunological and hemostasiological disorders in women with ovarian hyperstimulation syndrome.

To assess the markers of destabilization of homeostasis in women with ovarian hyperstimulation syndrome (OHSS), the investigation of the levels of cortisol, markers of renin-angiotensin-aldosterone system, endothelin, proinflammatory cytokines, acute phase proteins, and parameters of hemostasis was performed. Our survey involved 105 women who became pregnant after IVF: 21 women with symptoms of the early moderate and severe OHSS, 28 women with the late moderate and severe OHSS, and 56 pregnant women undergoing IVF without symptoms of OHSS. It was found significant increase of levels of cortisol, interleukins, the number of leucocytes, concentration of fibrinogen and D-dimers in patients with early and late OHSS.

Economic evaluation of Haemophilus influenzae type b vaccination in Moscow, Russian Federation.

Objective: To estimate the cost-effectiveness of providing Haemophilus influenzae type b (Hib) vaccine to children in Moscow in routine immunization services.

Methods: The incidence of Hib meningitis among children aged <5 years in Moscow was obtained from a prospective surveillance study undertaken during October 1999-September 2001, with treatment cost data collected for all cases. Sequelae in surviving children were assessed in December 2002.